NDFIP2
NDFIP2 is a protein in humans that is encoded by NDFIP2 gene. Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).
NDFIP2 Proteins
NDFIP2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP856339MO1 CSB-EP856339MO1 CSB-BP856339MO1 CSB-MP856339MO1 CSB-EP856339MO1-B |
Recombinant Mouse NEDD4 family-interacting protein 2 (Ndfip2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF856339MO | Recombinant Mouse NEDD4 family-interacting protein 2 (Ndfip2) | in vitro E.coli expression system |
NDFIP2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP885735HU1 CSB-EP885735HU1 CSB-BP885735HU1 CSB-MP885735HU1 CSB-EP885735HU1-B |
Recombinant Human NEDD4 family-interacting protein 2 (NDFIP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF885735HU | Recombinant Human NEDD4 family-interacting protein 2 (NDFIP2) | in vitro E.coli expression system |
