NCR3
NCR3，全稱為Natural cytotoxicity triggering receptor 3，也被稱為NKp30，是一種存在于自然殺傷細(xì)胞表面的跨膜蛋白。它屬于免疫球蛋白超家族，能夠識(shí)別并結(jié)合腫瘤細(xì)胞或病毒感染細(xì)胞表面的多種非MHC配體，如硫酸乙酰肝素糖胺聚糖（HS GAGs）和B7-H6等，從而激活NK細(xì)胞的細(xì)胞毒性作用，直接裂解靶細(xì)胞。NCR3的激活能夠調(diào)節(jié)NK細(xì)胞的細(xì)胞因子分泌功能，如干擾素-γ（IFN-γ）和腫瘤壞死因子-α（TNF-α）等，這些細(xì)胞因子能夠進(jìn)一步增強(qiáng)免疫反應(yīng)，清除感染或腫瘤細(xì)胞。NCR3在腫瘤免疫逃逸和抗病毒免疫中發(fā)揮著重要作用，其功能狀態(tài)可能影響腫瘤的發(fā)生發(fā)展以及病毒感染的慢性化進(jìn)程。目前，針對(duì)NCR3的治療策略主要包括使用單克隆抗體增強(qiáng)NCR3與配體的結(jié)合活性，或通過基因治療上調(diào)NK細(xì)胞表面NCR3的表達(dá)，以增強(qiáng)NK細(xì)胞的抗腫瘤活性。此外，部分小分子及生物制劑已進(jìn)入臨床驗(yàn)證階段，未來(lái)有望為腫瘤和感染性疾病患者帶來(lái)新的治療選擇。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human NCR3 at 5 μg/ml can bind human NCR3LG1(CSB-MP737873HU-B). The EC50 is 111.3-303.1 ng/mL.
The purity of NCR3 was greater than 95% as determined by SEC-HPLC
NCR3 Antibody (CSB-PA015551LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA015551LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA015551LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
NCR3 Antibodies
NCR3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006291 | NCR3 Antibody | Human,Rat | WB, ELISA |
| CSB-PA008587 | NCR3 Antibody | Human,Rat | WB, ELISA |
| CSB-PA031920 | NCR3 Antibody | Human | ELISA,IHC |
| CSB-PA899163 | NCR3 Antibody | Human | ELISA,IHC |
| CSB-PA015551LA01HU | NCR3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA015551LB01HU | NCR3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA015551LD01HU | NCR3 Antibody, Biotin conjugated | Human | ELISA |
NCR3 Proteins
NCR3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP015551HU1 CSB-EP015551HU1 CSB-BP015551HU1 CSB-EP015551HU1-B |
Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF015551HU | Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3) | in vitro E.coli expression system |
| CSB-MP015551HU1 | Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial (Active) | Mammalian cell |
NCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP015551MOV1 CSB-EP015551MOV1 CSB-BP015551MOV1 CSB-EP015551MOV1-B |
Recombinant Macaca fascicularis Natural cytotoxicity triggering receptor 3 (NCR3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF015551MOV | Recombinant Macaca fascicularis Natural cytotoxicity triggering receptor 3 (NCR3) | in vitro E.coli expression system |
NCR3 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP015551EQV1 CSB-EP015551EQV1 CSB-BP015551EQV1 CSB-MP015551EQV1 CSB-EP015551EQV1-B |
Recombinant Pan troglodytes Natural cytotoxicity triggering receptor 3 (NCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF015551EQV | Recombinant Pan troglodytes Natural cytotoxicity triggering receptor 3 (NCR3) | in vitro E.coli expression system |
NCR3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP015551RA CSB-EP015551RA CSB-BP015551RA CSB-MP015551RA CSB-EP015551RA-B |
Recombinant Rat Natural cytotoxicity triggering receptor 3 (Ncr3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NCR3 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP015551MOW CSB-EP015551MOW CSB-BP015551MOW CSB-MP015551MOW CSB-EP015551MOW-B |
Recombinant Macaca mulatta Natural cytotoxicity triggering receptor 3 (NCR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
