MUC13
MUC13（黏蛋白13）是一種高分子量的跨膜糖蛋白，通常在胃腸道和呼吸道上皮細(xì)胞表達(dá)，具有保護(hù)和潤(rùn)滑黏膜上皮的功能。它由α、β兩個(gè)亞基組成，包含N末端信號(hào)肽、串聯(lián)重復(fù)序列（TR）結(jié)構(gòu)域和SEA結(jié)構(gòu)域，MUC13基因包含12個(gè)外顯子，編碼511個(gè)氨基酸。MUC13通過(guò)促進(jìn)細(xì)胞增殖和遷移、抑制細(xì)胞凋亡和降低細(xì)胞黏附來(lái)參與多種病理過(guò)程。它在炎癥調(diào)節(jié)和腫瘤發(fā)展中扮演重要角色，特別是在多種上皮性腫瘤中，如胃癌、結(jié)直腸癌和卵巢癌，MUC13的異常表達(dá)已被廣泛觀察到。MUC13通過(guò)激活包括EGFR/PI3K/AKT、Wnt和NF-κB在內(nèi)的信號(hào)通路，影響腫瘤細(xì)胞的增殖、侵襲和存活。由于其在腫瘤發(fā)展中的潛在作用，MUC13被認(rèn)為是腫瘤早期診斷和治療的有希望的靶點(diǎn)，其研究有助于開(kāi)發(fā)新的癌癥治療策略。
熱銷(xiāo)產(chǎn)品
Recombinant Human Mucin-13(MUC13),partial (Active) (CSB-YP887973HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MUC13 at 2 μg/ml can bind Anti-MUC13 recombinant antibody (CSB-RA887973MA1HU). The EC50 is 2.592-2.923 ng/mL.
MUC13 Antibodies
MUC13 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA276815 | MUC13 Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA003335 | MUC13 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA237856 | MUC13 Antibody | Human | ELISA,IHC |
| CSB-PA131838 | MUC13 Antibody | Human | ELISA,IHC |
MUC13 Proteins
MUC13 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP887973HU CSB-BP887973HU CSB-EP887973HU-B |
Recombinant Human Mucin-13 (MUC13), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-YP887973HU | Recombinant Human Mucin-13(MUC13),partial (Active) | yeast |
| CSB-MP887973HU | Recombinant Human Mucin-13(MUC13),partial (Active) | Mammalian cell |
