MORC3
MORC3，即微管組織蛋白，別名KIAA0136、ZCWCC3、NXP2。它是一種核基質(zhì)蛋白，具有核基質(zhì)結(jié)合結(jié)構(gòu)域，含有推定的RNA結(jié)合位點(diǎn)，對(duì)轉(zhuǎn)錄調(diào)控至關(guān)重要。MORC3在免疫細(xì)胞中的表達(dá)水平較高，且在化療后正常外周血白細(xì)胞中的表達(dá)明顯上調(diào)，表明它可能參與調(diào)節(jié)細(xì)胞存活與細(xì)胞凋亡。MORC3通過(guò)激活p53并將其定位于早幼粒細(xì)胞白血病（PML）核體內(nèi)，誘導(dǎo)p53依賴的細(xì)胞衰老。此外，MORC3還參與DNA損傷修復(fù)和表觀遺傳調(diào)控，其異常表達(dá)與癌癥、自身免疫疾病和骨病相關(guān)。MORC3的功能區(qū)圖譜揭示了它在多種基本生物學(xué)過(guò)程中的作用，包括信號(hào)依賴的染色質(zhì)重塑和表觀遺傳調(diào)控，促進(jìn)脂肪生成，參與癌癥發(fā)生和骨穩(wěn)態(tài)調(diào)節(jié)。
熱銷產(chǎn)品
Recombinant Human MORC family CW-type zinc finger protein 3 (MORC3), partial (CSB-EP622753HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP622753HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MORC3.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP622753HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MORC3.
MORC3 Proteins
MORC3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP622753HU CSB-BP622753HU CSB-MP622753HU CSB-EP622753HU-B |
Recombinant Human MORC family CW-type zinc finger protein 3 (MORC3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP622753HU | Recombinant Human MORC family CW-type zinc finger protein 3 (MORC3), partial | E.coli |
