MICB
MICB，全稱為MHC class I polypeptide-related sequence B，是一種跨膜糖蛋白，屬于人組織相容性復(fù)合體I類相關(guān)基因家族。該蛋白常見別名包括MHC class I antigen-related protein B、MHC class I chain-related protein B等。MICB蛋白在正常細(xì)胞中表達(dá)量極低，主要在上皮性腫瘤細(xì)胞表面表達(dá)，并且可以被細(xì)菌和病毒感染誘導(dǎo)表達(dá)。因此，MICB蛋白的識別與腫瘤監(jiān)測、病毒感染和自身免疫性疾病的預(yù)防密切相關(guān)。
MICB蛋白作為人NKG2D II 型受體的配體，能夠與NK細(xì)胞表面的NKG2D受體結(jié)合，從而激活NK細(xì)胞的殺傷活性。這一作用機(jī)制使得MICB蛋白在免疫系統(tǒng)中扮演著重要的角色，能夠幫助機(jī)體清除異常細(xì)胞。此外，MICB蛋白的表達(dá)水平與多種疾病的發(fā)生發(fā)展密切相關(guān)，如消化系腫瘤、終末期腎病等。在藥物研發(fā)方面，針對MICB蛋白的靶向治療正在積極探索中，以期開發(fā)出更加有效的腫瘤治療藥物。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MICB at 2 μg/ml can bind Anti-MICA/B recombinant antibody (CSB-RA56059MA1HU). The EC50 is 1.087-1.369 ng/mL.
Human MHC class I polypeptide-related sequence B(MICB) ELISA kit (CSB-EL013813HU)
驗證數(shù)據(jù)
貨號：CSB-EL013813HU
規(guī)格：96T/48T
靈敏度：7.8 pg/mL
檢測范圍：31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MICB Proteins
MICB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-BP013813HU CSB-EP013813HU-B |
Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP000271HU | Recombinant Human MHC class I polypeptide-related sequence B protein (MICB) | E.Coli |
| CSB-MP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Mammalian cell |
| CSB-EP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | E.coli |
| CSB-YP013813HU | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial | Yeast |
| CSB-MP013813HUd7 | Recombinant Human MHC class I polypeptide-related sequence B (MICB), partial (Active) | Mammalian cell |
MICB ELISA Kit
MICB ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013813HU | Human MHC class I polypeptide-related sequence B(MICB) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
