MGMT
MGMT，全稱為O6-甲基鳥嘌呤-DNA甲基轉(zhuǎn)移酶，是一種重要的DNA修復(fù)蛋白，主要作用是修復(fù)DNA損傷，保護(hù)細(xì)胞免受烷化劑的致癌和致突變作用。MGMT蛋白在多種腫瘤中表達(dá)下調(diào)，與腫瘤耐藥性密切相關(guān)。例如，在膠質(zhì)瘤中，MGMT表達(dá)水平與腫瘤的耐藥性以及患者的預(yù)后相關(guān)。目前，針對(duì)MGMT的藥物研發(fā)進(jìn)展迅速，如Paxalisib等藥物正在臨床試驗(yàn)中，有望為膠質(zhì)瘤患者提供新的治療選擇。此外，MGMT的表達(dá)還與肺癌、結(jié)直腸癌等多種癌癥的發(fā)生發(fā)展有關(guān)，因此，MGMT也是癌癥研究和治療的重要靶點(diǎn)。
熱銷產(chǎn)品
MGMT Recombinant Monoclonal Antibody (CSB-RA966553A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Jurkat whole cell lysate
All lanes: MGMT antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 22 kDa
Observed band size: 22 kDa
IHC image of CSB-RA966553A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
MGMT Antibodies
MGMT for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013788GA01HU | MGMT Antibody | Human | ELISA,WB,IHC |
| CSB-PA11859A0Rb | MGMT Antibody | Human | ELISA, IHC |
| CSB-PA563873 | MGMT Antibody | Human,Rat | ELISA,WB |
| CSB-PA003238 | MGMT Antibody | Human,Rat | WB, IHC, ELISA |
| CSB-PA821117 | MGMT Antibody | Human | ELISA,WB |
| CSB-RA966553A0HU | MGMT Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
MGMT Proteins
MGMT Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013788HU CSB-EP013788HU CSB-BP013788HU CSB-MP013788HU CSB-EP013788HU-B |
Recombinant Human Methylated-DNA--protein-cysteine methyltransferase (MGMT) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
