MC4R
MC4R，即黑皮質素4受體”，別名Melanocortin 4 Receptor、Melanocortin Receptor 4、MC4-R、Mutant Melanocortin-4 Receptor等。它是一種膜結合受體，屬于黑皮質素受體家族成員，由人體細胞自身的基因編碼。MC4R主要在下丘腦中表達，參與控制食物攝取、能量消耗和體重維持等 。MC4R的作用機制主要是通過與黑皮質素激素如α-黑素細胞刺激激素（α-MSH）等內源性配體結合，通過G蛋白偶聯的方式激活腺苷酸環化酶（cAMP）信號通路，從而發出飽腹感信號，減少食物攝入。MC4R的激活還涉及多種代謝信號的處理，如瘦素、饑餓素和神經肽Y (NPY)等，調節人體能量代謝和進食行為 。MC4R在生物學上的意義非常重大，它不僅參與了能量平衡和體重調節，還與多種代謝性疾病的發生發展密切相關。例如，MC4R的功能異常或突變與肥胖癥有關，MC4R激動劑如setmelanotide已被批準用于治療某些類型的肥胖癥。此外，MC4R的激活還可能影響情緒、獎賞和認知功能，對心理健康和行為也有潛在影響 。
熱銷產品
驗證數據
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
MC4R Antibodies
MC4R for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010101 | MC4R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA934831 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA254627 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA013561LA01HU | MC4R Antibody | Human | ELISA, IHC |
| CSB-PA013561LB01HU | MC4R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013561LC01HU | MC4R Antibody, FITC conjugated | Human | |
| CSB-PA013561LD01HU | MC4R Antibody, Biotin conjugated | Human | ELISA |
MC4R Proteins
MC4R Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013561RA1 CSB-EP013561RA1 CSB-BP013561RA1 CSB-MP013561RA1 CSB-EP013561RA1-B |
Recombinant Rat Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561RA | Recombinant Rat Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
MC4R Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013561HU1 CSB-EP013561HU1 CSB-BP013561HU1 CSB-MP013561HU1 CSB-EP013561HU1-B |
Recombinant Human Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561HU | Recombinant Human Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013561MO1 CSB-EP013561MO1 CSB-BP013561MO1 CSB-MP013561MO1 CSB-EP013561MO1-B |
Recombinant Mouse Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561MO | Recombinant Mouse Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
MC4R Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP013561PI1 CSB-EP013561PI1 CSB-BP013561PI1 CSB-MP013561PI1 CSB-EP013561PI1-B |
Recombinant Pig Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561PI | Recombinant Pig Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Vulpes vulpes (Red fox)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP604515VFW1 CSB-EP604515VFW1 CSB-BP604515VFW1 CSB-MP604515VFW1 CSB-EP604515VFW1-B |
Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF604515VFW | Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP808487MOV1 CSB-EP808487MOV1 CSB-BP808487MOV1 CSB-MP808487MOV1 CSB-EP808487MOV1-B |
Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF808487MOV | Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP872388BO1 CSB-EP872388BO1 CSB-BP872388BO1 CSB-MP872388BO1 CSB-EP872388BO1-B |
Recombinant Bovine Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF872388BO | Recombinant Bovine Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
