MC4R
MC4R，即黑皮質(zhì)素4受體”，別名Melanocortin 4 Receptor、Melanocortin Receptor 4、MC4-R、Mutant Melanocortin-4 Receptor等。它是一種膜結(jié)合受體，屬于黑皮質(zhì)素受體家族成員，由人體細(xì)胞自身的基因編碼。MC4R主要在下丘腦中表達(dá)，參與控制食物攝取、能量消耗和體重維持等 。MC4R的作用機(jī)制主要是通過與黑皮質(zhì)素激素如α-黑素細(xì)胞刺激激素（α-MSH）等內(nèi)源性配體結(jié)合，通過G蛋白偶聯(lián)的方式激活腺苷酸環(huán)化酶（cAMP）信號通路，從而發(fā)出飽腹感信號，減少食物攝入。MC4R的激活還涉及多種代謝信號的處理，如瘦素、饑餓素和神經(jīng)肽Y (NPY)等，調(diào)節(jié)人體能量代謝和進(jìn)食行為 。MC4R在生物學(xué)上的意義非常重大，它不僅參與了能量平衡和體重調(diào)節(jié)，還與多種代謝性疾病的發(fā)生發(fā)展密切相關(guān)。例如，MC4R的功能異常或突變與肥胖癥有關(guān)，MC4R激動劑如setmelanotide已被批準(zhǔn)用于治療某些類型的肥胖癥。此外，MC4R的激活還可能影響情緒、獎(jiǎng)賞和認(rèn)知功能，對心理健康和行為也有潛在影響 。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
MC4R Antibodies
MC4R for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010101 | MC4R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA934831 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA254627 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA013561LA01HU | MC4R Antibody | Human | ELISA, IHC |
| CSB-PA013561LB01HU | MC4R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013561LC01HU | MC4R Antibody, FITC conjugated | Human | |
| CSB-PA013561LD01HU | MC4R Antibody, Biotin conjugated | Human | ELISA |
MC4R Proteins
MC4R Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013561RA1 CSB-EP013561RA1 CSB-BP013561RA1 CSB-MP013561RA1 CSB-EP013561RA1-B |
Recombinant Rat Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561RA | Recombinant Rat Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
MC4R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013561HU1 CSB-EP013561HU1 CSB-BP013561HU1 CSB-MP013561HU1 CSB-EP013561HU1-B |
Recombinant Human Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561HU | Recombinant Human Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013561MO1 CSB-EP013561MO1 CSB-BP013561MO1 CSB-MP013561MO1 CSB-EP013561MO1-B |
Recombinant Mouse Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561MO | Recombinant Mouse Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
MC4R Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013561PI1 CSB-EP013561PI1 CSB-BP013561PI1 CSB-MP013561PI1 CSB-EP013561PI1-B |
Recombinant Pig Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561PI | Recombinant Pig Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Vulpes vulpes (Red fox)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP604515VFW1 CSB-EP604515VFW1 CSB-BP604515VFW1 CSB-MP604515VFW1 CSB-EP604515VFW1-B |
Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF604515VFW | Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP808487MOV1 CSB-EP808487MOV1 CSB-BP808487MOV1 CSB-MP808487MOV1 CSB-EP808487MOV1-B |
Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF808487MOV | Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
MC4R Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872388BO1 CSB-EP872388BO1 CSB-BP872388BO1 CSB-MP872388BO1 CSB-EP872388BO1-B |
Recombinant Bovine Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF872388BO | Recombinant Bovine Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
