MAP3K8
Mitogen-activated protein kinase kinase kinase 8 is a protein in humans that is encoded by MAP3K8 gene. Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
MAP3K8 Antibodies
MAP3K8 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA588716 | Phospho-MAP3K8 (Ser400) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA901361 | MAP3K8 (Ab-400) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA000735 | Phospho-MAP3K8 (T290) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA001760 | MAP3K8 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007155 | Phospho-MAP3K8 (S400) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA007158 | MAP3K8 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA013433LA01HU | MAP3K8 Antibody | Human | ELISA, IHC, IF |
| CSB-PA013433LC01HU | MAP3K8 Antibody, FITC conjugated | Human | |
| CSB-PA013433LD01HU | MAP3K8 Antibody, Biotin conjugated | Human | ELISA |
MAP3K8 Proteins
MAP3K8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013433HU CSB-EP013433HU CSB-BP013433HU CSB-MP013433HU CSB-EP013433HU-B |
Recombinant Human Mitogen-activated protein kinase kinase kinase 8 (MAP3K8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAP3K8 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013433RA CSB-EP013433RA CSB-BP013433RA CSB-MP013433RA CSB-EP013433RA-B |
Recombinant Rat Mitogen-activated protein kinase kinase kinase 8 (Map3k8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
