LPAR1
LPAR1，全稱為溶血磷脂酸受體1（Lysophosphatidic Acid Receptor 1），常見(jiàn)別名為EDG2、Gpcr26等。該蛋白主要參與細(xì)胞增殖、遷移和存活等過(guò)程，與多種疾病密切相關(guān)，如纖維化、腫瘤、神經(jīng)性疼痛等。LPAR1通過(guò)結(jié)合溶血磷脂酸（LPA）發(fā)揮功能，激活下游信號(hào)通路，影響細(xì)胞行為。在疾病方面，LPAR1過(guò)度激活與肺纖維化、類(lèi)風(fēng)濕性關(guān)節(jié)炎等慢性炎癥性疾病有關(guān)。針對(duì)LPAR1的藥物研發(fā)已取得一定進(jìn)展，例如Gilead Sciences開(kāi)發(fā)的高效選擇性LPAR1拮抗劑GS-2278，在治療特發(fā)性肺纖維化方面展現(xiàn)出顯著療效，但因其中樞神經(jīng)系統(tǒng)毒性而終止臨床開(kāi)發(fā)。此外，百時(shí)美施貴寶的Admilparant也在進(jìn)行中，旨在治療肺纖維化等疾病。這些研究為L(zhǎng)PAR1相關(guān)疾病的治療提供了新的思路和策略。
熱銷(xiāo)產(chǎn)品
LPAR1 Recombinant Monoclonal Antibody (CSB-RA922556A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate
All lanes: EDG2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 42 kDa
Observed band size: 42 kDa
LPAR1 Antibodies
LPAR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA007901 | LPAR1 Antibody | Human,Rat | WB, IHC, IF, ELISA |
| CSB-PA583502 | LPAR1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA559394 | LPAR1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA013047LA01HU | LPAR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA013047LB01HU | LPAR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA922556A0HU | LPAR1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
LPAR1 Proteins
LPAR1 Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013047SH1 CSB-EP013047SH1 CSB-BP013047SH1 CSB-MP013047SH1 CSB-EP013047SH1-B |
Recombinant Sheep Lysophosphatidic acid receptor 1 (LPAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013047SH | Recombinant Sheep Lysophosphatidic acid receptor 1 (LPAR1) | in vitro E.coli expression system |
LPAR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013047MO1 CSB-EP013047MO1 CSB-BP013047MO1 CSB-MP013047MO1 CSB-EP013047MO1-B |
Recombinant Mouse Lysophosphatidic acid receptor 1 (Lpar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013047MO | Recombinant Mouse Lysophosphatidic acid receptor 1 (Lpar1) | in vitro E.coli expression system |
LPAR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013047RA1 CSB-EP013047RA1 CSB-BP013047RA1 CSB-MP013047RA1 CSB-EP013047RA1-B |
Recombinant Rat Lysophosphatidic acid receptor 1 (Lpar1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013047RA | Recombinant Rat Lysophosphatidic acid receptor 1 (Lpar1) | in vitro E.coli expression system |
LPAR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013047HU1 CSB-EP013047HU1 CSB-BP013047HU1 CSB-MP013047HU1 CSB-EP013047HU1-B |
Recombinant Human Lysophosphatidic acid receptor 1 (LPAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013047HU | Recombinant Human Lysophosphatidic acid receptor 1 (LPAR1) | in vitro E.coli expression system |
LPAR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP013047BO1 CSB-EP013047BO1 CSB-BP013047BO1 CSB-MP013047BO1 CSB-EP013047BO1-B |
Recombinant Bovine Lysophosphatidic acid receptor 1 (LPAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013047BO | Recombinant Bovine Lysophosphatidic acid receptor 1 (LPAR1) | in vitro E.coli expression system |
