LIMK1
LIM domain kinase 1 is a protein in humans that is encoded by LIMK1 gene. Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development.
LIMK1 Antibodies
LIMK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012952GA01HU | LIMK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA697195 | Phospho-LIMK1 (Thr508) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA828577 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000566 | Phospho-LIMK1 (T508) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA003150 | LIMK1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA009830 | LIMK1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA782037 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA042400 | LIMK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA012952LA01HU | LIMK1 Antibody | Human | ELISA, IHC |
| CSB-PA012952LB01HU | LIMK1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012952LC01HU | LIMK1 Antibody, FITC conjugated | Human | |
| CSB-PA012952LD01HU | LIMK1 Antibody, Biotin conjugated | Human | ELISA |
LIMK1 Proteins
LIMK1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952MO CSB-EP012952MO CSB-BP012952MO CSB-MP012952MO CSB-EP012952MO-B |
Recombinant Mouse LIM domain kinase 1 (Limk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952HU CSB-EP012952HU CSB-BP012952HU CSB-EP012952HU-B |
Recombinant Human LIM domain kinase 1 (LIMK1) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952RA CSB-EP012952RA CSB-BP012952RA CSB-MP012952RA CSB-EP012952RA-B |
Recombinant Rat LIM domain kinase 1 (Limk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952XBE CSB-EP012952XBE CSB-BP012952XBE CSB-MP012952XBE CSB-EP012952XBE-B |
Recombinant Xenopus laevis LIM domain kinase 1 (limk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952DLU CSB-EP012952DLU CSB-BP012952DLU CSB-MP012952DLU CSB-EP012952DLU-B |
Recombinant Drosophila melanogaster LIM domain kinase 1 (LIMK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LIMK1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012952CH CSB-EP012952CH CSB-BP012952CH CSB-MP012952CH CSB-EP012952CH-B |
Recombinant Chicken LIM domain kinase 1 (LIMK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
