LECT2
LECT2，全稱為 Leukocyte Cell-Derived Chemotaxin 2，是一種分泌型蛋白，主要由肝細(xì)胞產(chǎn)生，在肝與其他器官的相互作用中發(fā)揮重要作用。LECT2 蛋白除了具有趨化中性粒細(xì)胞的作用外，還與多種肝臟疾病的發(fā)生發(fā)展密切相關(guān)，如急性肝炎、肝淀粉樣變性、非酒精性脂肪肝、非酒精性脂肪性肝炎、肝纖維化和肝細(xì)胞癌等。研究表明，LECT2 蛋白在肝細(xì)胞癌中具有抑癌作用，能夠抑制腫瘤細(xì)胞的增殖、遷移、侵襲和上皮間質(zhì)轉(zhuǎn)化等惡性行為，并抑制肝癌干細(xì)胞的自我更新和藥物外排功能。此外，LECT2 蛋白還參與調(diào)控血管生成，其表達(dá)水平與血管生成相關(guān)因子的水平呈負(fù)相關(guān)。目前，針對(duì) LECT2 蛋白的藥物研發(fā)尚處于起步階段，但已有研究表明，靶向 LECT2 蛋白的治療策略可能成為治療肝細(xì)胞癌和肝纖維化等疾病的新途徑。
熱銷產(chǎn)品
LECT2 Antibody (CSB-PA012855LA01HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA012855LA01HU diluted at 1:400 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Leukocyte cell-derived chemotaxin-2(LECT2) ELISA kit (CSB-EL012855HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL012855HU
規(guī)格：96T/48T
靈敏度：0.39 ng/mL
檢測(cè)范圍：1.56 ng/mL-100 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LECT2 Antibodies
LECT2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012855GA01HU | LECT2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA012855LA01HU | LECT2 Antibody | Human | ELISA, IHC |
| CSB-PA012855LB01HU | LECT2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012855LC01HU | LECT2 Antibody, FITC conjugated | Human | |
| CSB-PA012855LD01HU | LECT2 Antibody, Biotin conjugated | Human | ELISA |
LECT2 Proteins
LECT2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012855HU CSB-EP012855HU CSB-BP012855HU CSB-MP012855HU CSB-EP012855HU-B |
Recombinant Human Leukocyte cell-derived chemotaxin-2 (LECT2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LECT2 ELISA Kit
LECT2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL012855HU | Human Leukocyte cell-derived chemotaxin-2(LECT2) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 0.39 ng/mL |
