LDLRAP1
Low density lipoprotein receptor adapter protein 1 is a protein in humans that is encoded by LDLRAP1 gene. Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
LDLRAP1 Antibodies
LDLRAP1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012850GA01HU | LDLRAP1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA729190ESR1HU | LDLRAP1 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA729190ESR2HU | LDLRAP1 Antibody | Human | ELISA, IHC |
LDLRAP1 Proteins
LDLRAP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP729190HU CSB-EP729190HU CSB-BP729190HU CSB-MP729190HU CSB-EP729190HU-B |
Recombinant Human Low density lipoprotein receptor adapter protein 1 (LDLRAP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LDLRAP1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP806007MO CSB-EP806007MO CSB-BP806007MO CSB-MP806007MO CSB-EP806007MO-B |
Recombinant Mouse Low density lipoprotein receptor adapter protein 1 (Ldlrap1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
