LATS2
Serine/threonine-protein kinase LATS2 is a protein in humans that is encoded by LATS2 gene. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
LATS2 Antibodies
LATS2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012770GA01HU | LATS2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA008767 | LATS2 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA697830 | LATS2 Antibody | Human,Mouse | ELISA,IHC |
LATS2 Proteins
LATS2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP766520MO CSB-EP766520MO CSB-BP766520MO CSB-MP766520MO CSB-EP766520MO-B |
Recombinant Mouse Serine/threonine-protein kinase LATS2 (Lats2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LATS2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP878870HU CSB-EP878870HU CSB-BP878870HU CSB-MP878870HU CSB-EP878870HU-B |
Recombinant Human Serine/threonine-protein kinase LATS2 (LATS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
