LATS1
Serine/threonine-protein kinase LATS1 is a protein in humans that is encoded by LATS1 gene. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
LATS1 Antibodies
LATS1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012769GA01HU | LATS1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA830665 | LATS1 Antibody | Human | ELISA,IHC |
| CSB-PA012769LA01HU | LATS1 Antibody | Human | ELISA, IHC, IF, IP |
| CSB-PA012769LB01HU | LATS1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012769LC01HU | LATS1 Antibody, FITC conjugated | Human | |
| CSB-PA012769LD01HU | LATS1 Antibody, Biotin conjugated | Human | ELISA |
LATS1 Proteins
LATS1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012769HU CSB-BP012769HU CSB-MP012769HU CSB-EP012769HU-B |
Recombinant Human Serine/threonine-protein kinase LATS1 (LATS1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012769HU | Recombinant Human Serine/threonine-protein kinase LATS1 (LATS1), partial | E.coli |
LATS1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP803964MO CSB-EP803964MO CSB-BP803964MO CSB-MP803964MO CSB-EP803964MO-B |
Recombinant Mouse Serine/threonine-protein kinase LATS1 (Lats1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
