LAIR1
LAIR1，即白細(xì)胞相關(guān)免疫球蛋白樣受體1，別名CD305、LAIR-1。它主要在多種免疫細(xì)胞上表達(dá)，包括自然殺傷細(xì)胞、T細(xì)胞和B細(xì)胞。LAIR1的作用機(jī)制涉及與其高親和力配體膠原蛋白的結(jié)合，這一結(jié)合能夠誘導(dǎo)LAIR1上的免疫受體酪氨酸基抑制基序（ITIMs）的自體磷酸化，進(jìn)而招募如Src同源區(qū)域含磷酸酶SHP-1和SHP-2等磷酸酶，調(diào)節(jié)負(fù)向信號(hào)。LAIR1作為一種抑制性受體，通過(guò)調(diào)節(jié)免疫反應(yīng)，防止自身細(xì)胞被裂解，同時(shí)在腫瘤微環(huán)境中，膠原蛋白/LAIR1信號(hào)在下調(diào)抗腫瘤反應(yīng)中發(fā)揮重要作用。LAIR1的異常表達(dá)與多種癌癥的發(fā)展相關(guān)，包括白血病、卵巢癌、腎癌、口腔鱗狀細(xì)胞癌和肝細(xì)胞癌，其在腫瘤免疫逃逸和免疫治療中可能作為潛在的生物標(biāo)志物。
熱銷產(chǎn)品
LAIR1 Antibody (CSB-PA012721LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA012721LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA012721LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA012721LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
LAIR1 Antibodies
LAIR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006294 | LAIR1 Antibody | Human | WB, ELISA |
| CSB-PA088669 | LAIR1 Antibody | Human | ELISA,IHC |
| CSB-PA694004 | LAIR1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA012721LA01HU | LAIR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA012721LB01HU | LAIR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012721LC01HU | LAIR1 Antibody, FITC conjugated | Human | |
| CSB-PA012721LD01HU | LAIR1 Antibody, Biotin conjugated | Human | ELISA |
LAIR1 Proteins
LAIR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012721RA1 CSB-EP012721RA1 CSB-BP012721RA1 CSB-MP012721RA1 CSB-EP012721RA1-B |
Recombinant Rat Leukocyte-associated immunoglobulin-like receptor 1 (Lair1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012721RA | Recombinant Rat Leukocyte-associated immunoglobulin-like receptor 1 (Lair1) | in vitro E.coli expression system |
LAIR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012721HU CSB-EP012721HU CSB-BP012721HU CSB-MP012721HU CSB-EP012721HU-B |
Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LAIR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP012721MO CSB-EP012721MO CSB-BP012721MO CSB-MP012721MO CSB-EP012721MO-B |
Recombinant Mouse Leukocyte-associated immunoglobulin-like receptor 1 (Lair1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
