KRIT1
Krev interaction trapped protein 1 is a protein in humans that is encoded by KRIT1 gene. Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization.
KRIT1 Antibodies
KRIT1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012501LA01HU | KRIT1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA012501LC01HU | KRIT1 Antibody, FITC conjugated | Human | |
| CSB-PA012501LD01HU | KRIT1 Antibody, Biotin conjugated | Human | ELISA |
KRIT1 Proteins
KRIT1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012501HU CSB-EP012501HU CSB-BP012501HU CSB-MP012501HU CSB-EP012501HU-B |
Recombinant Human Krev interaction trapped protein 1 (KRIT1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KRIT1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012501DIL CSB-EP012501DIL CSB-BP012501DIL CSB-MP012501DIL CSB-EP012501DIL-B |
Recombinant Danio rerio Krev interaction trapped protein 1 (krit1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KRIT1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP740859MO CSB-EP740859MO CSB-BP740859MO CSB-MP740859MO CSB-EP740859MO-B |
Recombinant Mouse Krev interaction trapped protein 1 (Krit1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KRIT1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP754378BO CSB-EP754378BO CSB-BP754378BO CSB-MP754378BO CSB-EP754378BO-B |
Recombinant Bovine Krev interaction trapped protein 1 (KRIT1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
