KMT2D
KMT2D，即賴氨酸甲基轉(zhuǎn)移酶2D，別名MLL2、ALR、KABUKI綜合癥相關(guān)蛋白等。它是一種由KMT2D基因編碼的酶，屬于KMT2家族成員，在細(xì)胞核中發(fā)揮作用。KMT2D的作用機(jī)制主要是通過催化組蛋白H3賴氨酸4的單甲基化和雙甲基化，參與調(diào)控基因表達(dá)和增強(qiáng)子活性。KMT2D參與了細(xì)胞增殖、分化、腫瘤發(fā)展等過程。KMT2D的功能異常與多種疾病有關(guān)，包括癌癥、智力障礙、發(fā)育異常等。KMT2D在前列腺癌中通過調(diào)控特定基因表達(dá)，激活PI3K/AKT、EMT通路，促進(jìn)腫瘤生長及轉(zhuǎn)移。因此，KMT2D是腫瘤研究和治療中的潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA965267(KMT2D Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
KMT2D Antibodies
KMT2D for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA965267 | KMT2D Antibody | Human | ELISA,IHC |
KMT2D Proteins
KMT2D Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014628HU CSB-EP014628HU CSB-BP014628HU CSB-MP014628HU CSB-EP014628HU-B |
Recombinant Human Histone-lysine N-methyltransferase 2D (KMT2D), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KMT2D Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744111MO CSB-EP744111MO CSB-BP744111MO CSB-MP744111MO CSB-EP744111MO-B |
Recombinant Mouse Histone-lysine N-methyltransferase MLL2 (Mll2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
