KLRG1
殺傷細胞凝集素樣受體G1（KLRG1）又稱CLEC15A，是表達于自然殺傷細胞和T細胞表面的免疫抑制性受體。KLRG1通過識別E-鈣黏蛋白等配體傳遞抑制信號，參與調控免疫細胞活化閾值，在維持免疫穩態中起重要作用。慢性病毒感染患者和腫瘤微環境中的T細胞常呈現KLRG1高表達，這種終末分化表型與細胞增殖能力下降密切相關，可能影響抗病毒或抗腫瘤免疫應答。在自身免疫性疾病領域，KLRG1陽性調節性T細胞亞群顯示出更強的免疫抑制功能，其動態變化與多發性硬化等疾病進程存在關聯。近年針對免疫檢查點的藥物開發中，KLRG1作為潛在靶點受到關注，已有研究團隊開發出阻斷性抗體，在黑色素瘤等動物模型中觀察到聯合治療可增強PD-1抑制劑療效。但相較于成熟靶點，其轉化醫學研究仍處于早期階段，配體互作網絡與下游信號傳導的具體機制尚待深入解析。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KLRG1 Recombinant Monoclonal Antibody (CSB-RA233042A0HU)
驗證數據
Overlay Peak curve showing A549 cells surface stained with CSB-RA233042A0HU (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
KLRG1 Antibodies
KLRG1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA846610LA01HU | KLRG1 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA846610LB01HU | KLRG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA846610LC01HU | KLRG1 Antibody, FITC conjugated | Human | |
| CSB-PA012472GA01HU | KLRG1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA233042A0HU | KLRG1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
KLRG1 Proteins
KLRG1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012472MO1 CSB-BP012472MO1 CSB-MP012472MO1 CSB-EP012472MO1-B |
Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012472MO | Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1) | in vitro E.coli expression system |
| CSB-EP012472MO1 | Recombinant Mouse Killer cell lectin-like receptor subfamily G member 1 (Klrg1), partial | E.coli |
KLRG1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP737353RA CSB-EP737353RA CSB-BP737353RA CSB-MP737353RA CSB-EP737353RA-B |
Recombinant Rat Killer cell lectin-like receptor subfamily G member 1 (Klrg1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRG1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP846610HU CSB-BP846610HU CSB-MP846610HU CSB-EP846610HU-B |
Recombinant Human Killer cell lectin-like receptor subfamily G member 1 (KLRG1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP846610HU | Recombinant Human Killer cell lectin-like receptor subfamily G member 1 (KLRG1), partial | E.coli |
