KLRD1
KLRD1全稱為殺傷細胞凝集素樣受體亞家族D成員1，常被稱為CD94抗原或NKG2受體復合體組成部分。該蛋白主要分布于自然殺傷細胞（NK細胞）和部分T細胞表面，通過與NKG2家族蛋白（如NKG2A/C）結合形成異源二聚體，參與識別細胞表面的HLA-E分子。這種識別過程在免疫監視中發揮關鍵作用，既能抑制NK細胞對正常組織的攻擊，又能激活對異常細胞（如病毒感染或癌變細胞）的殺傷功能。KLRD1表達水平異常與多種疾病相關，例如類風濕性關節炎患者的NK細胞中CD94表達顯著升高，而在慢性病毒感染或實體腫瘤微環境中，受體功能失調可能導致免疫逃逸。針對NK細胞受體的藥物研發成為熱點，已有抗體藥物通過阻斷抑制性受體（如NKG2A）來增強抗腫瘤免疫，相關療法在頭頸癌、血液腫瘤等領域進入臨床試驗階段。此外，基于CD94/NKG2調控機制的細胞療法也在探索中，為感染性疾病和癌癥提供新的干預策略。
熱銷產品
Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial (CSB-MP615672HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KLRD1 Antibody (CSB-PA615672LA01HU)
驗證數據
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA615672LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA615672LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA615672LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
KLRD1 Antibodies
KLRD1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012470GA01HU | KLRD1 Antibody | Human | ELISA,WB |
| CSB-PA615672LA01HU | KLRD1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA615672LC01HU | KLRD1 Antibody, FITC conjugated | Human | |
| CSB-PA615672LD01HU | KLRD1 Antibody, Biotin conjugated | Human | ELISA |
KLRD1 Proteins
KLRD1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012470RA1 CSB-EP012470RA1 CSB-BP012470RA1 CSB-MP012470RA1 CSB-EP012470RA1-B |
Recombinant Rat Natural killer cells antigen CD94 (Klrd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012470RA | Recombinant Rat Natural killer cells antigen CD94 (Klrd1) | in vitro E.coli expression system |
KLRD1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP012470MO1 CSB-EP012470MO1 CSB-BP012470MO1 CSB-MP012470MO1 CSB-EP012470MO1-B |
Recombinant Mouse Natural killer cells antigen CD94 (Klrd1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012470MO | Recombinant Mouse Natural killer cells antigen CD94 (Klrd1) | in vitro E.coli expression system |
KLRD1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP615672HU CSB-EP615672HU CSB-BP615672HU CSB-EP615672HU-B |
Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP615672HU | Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial | Mammalian cell |
KLRD1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP655045DO CSB-EP655045DO CSB-BP655045DO CSB-MP655045DO CSB-EP655045DO-B |
Recombinant Dog Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP768113BO CSB-EP768113BO CSB-BP768113BO CSB-MP768113BO CSB-EP768113BO-B |
Recombinant Bovine Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP853978EXP CSB-EP853978EXP CSB-BP853978EXP CSB-MP853978EXP CSB-EP853978EXP-B |
Recombinant Pongo pygmaeus Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP873550MOW CSB-EP873550MOW CSB-BP873550MOW CSB-MP873550MOW CSB-EP873550MOW-B |
Recombinant Macaca mulatta Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
KLRD1 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP882002EQV CSB-EP882002EQV CSB-BP882002EQV CSB-MP882002EQV CSB-EP882002EQV-B |
Recombinant Pan troglodytes Natural killer cells antigen CD94 (KLRD1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
