KLK1

KLK1全稱為激肽釋放酶1，又稱組織激肽釋放酶或hK1，是絲氨酸蛋白酶家族成員。該蛋白在人體多個(gè)組織表達(dá)，能夠水解低分子量激肽原生成活性激肽，參與調(diào)節(jié)血壓、電解質(zhì)平衡及炎癥反應(yīng)過程。KLK1與緩激肽系統(tǒng)存在密切關(guān)聯(lián)，在血管舒張、細(xì)胞增殖等生理活動(dòng)中扮演關(guān)鍵角色。
KLK1異常表達(dá)與高血壓、慢性腎病及動(dòng)脈粥樣硬化等疾病相關(guān)，尤其在糖尿病腎病患者的尿液中常檢測(cè)到濃度升高。近年來，基于其調(diào)節(jié)血壓的特性，科研團(tuán)隊(duì)嘗試開發(fā)重組激肽釋放酶1作為治療缺血性中風(fēng)和心肌梗死的候選藥物。同時(shí)，針對(duì)其抑制劑的研究也在推進(jìn)中，用于緩解激肽過度釋放引發(fā)的炎癥反應(yīng)。目前已有部分小分子化合物進(jìn)入臨床前研究階段，但成藥性仍需進(jìn)一步驗(yàn)證。

熱銷產(chǎn)品

Recombinant Human Kallikrein-1 (KLK1) (CSB-EP012446HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLK1 Antibody (CSB-PA012446LA01HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA012446LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Kallikrein 1,KLK 1 ELISA Kit (CSB-E11437h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E11437h

規(guī)格：96T/48T

靈敏度：0.195 ng/mL

檢測(cè)范圍：0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KLK1 Antibody

KLK1 Protein

KLK1 ELISA Kit

KLK1 Antibodies

KLK1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA012446LA01HU	KLK1 Antibody	Human	ELISA, IHC, IF
CSB-PA012446LB01HU	KLK1 Antibody, HRP conjugated	Human	ELISA
CSB-PA012446LD01HU	KLK1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA012446GA01HU	KLK1 Antibody	Human	ELISA,WB,IHC
CSB-PA005798	KLK1 Antibody	Human	WB, ELISA
CSB-PA086611	KLK1 Antibody	Human	ELISA,IHC
CSB-PA248038	KLK1 Antibody	Human	ELISA,IHC

KLK1 Proteins

KLK1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012446MO CSB-EP012446MO CSB-BP012446MO CSB-MP012446MO CSB-EP012446MO-B	Recombinant Mouse Kallikrein-1 (Klk1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLK1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012446HU CSB-BP012446HU CSB-MP012446HU CSB-EP012446HU-B	Recombinant Human Kallikrein-1 (KLK1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012446HU	Recombinant Human Kallikrein-1 (KLK1)	E.coli

KLK1 Proteins for Papio hamadryas (Hamadryas baboon)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP637917ERJ CSB-EP637917ERJ CSB-BP637917ERJ CSB-MP637917ERJ CSB-EP637917ERJ-B	Recombinant Papio hamadryas Kallikrein-1 (KLK1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLK1 Proteins for Blarina brevicauda (Short-tailed shrew)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP710890BTI CSB-EP710890BTI CSB-BP710890BTI CSB-MP710890BTI CSB-EP710890BTI-B	Recombinant Blarina brevicauda Blarinasin-1 (KLK1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli