KLF1
KLF1，別名EKLF。KLF1是一種具有轉(zhuǎn)錄活性的鋅指蛋白，屬于KLF轉(zhuǎn)錄因子家族成員之一。KLF1通過(guò)其C端高度保守的3個(gè)串聯(lián)的C2H2鋅指序列組成的DNA結(jié)合結(jié)構(gòu)域，識(shí)別并結(jié)合到紅細(xì)胞相關(guān)基因的啟動(dòng)子或增強(qiáng)子中的CACCC序列，從而調(diào)控基因表達(dá)。KLF1是一個(gè)基本的紅細(xì)胞系特異性轉(zhuǎn)錄因子，參與細(xì)胞分化、增殖和腫瘤形成等過(guò)程。KLF1在紅細(xì)胞生成中發(fā)揮關(guān)鍵作用，通過(guò)直接激活KLF3基因，而KLF3激活后反饋性抑制KLF1驅(qū)動(dòng)的紅細(xì)胞增殖。KLF1還參與心臟損傷后的修復(fù)過(guò)程，能夠啟動(dòng)心肌細(xì)胞增殖。KLF1的表達(dá)異常可能與多種疾病的發(fā)生密切相關(guān)，包括心血管疾病和血液系統(tǒng)疾病。
熱銷產(chǎn)品
Recombinant Human Krueppel-like factor 1 (KLF1) (CSB-EP619760HUa6)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KLF1 Antibody (CSB-PA619760LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of Hela cells using CSB-PA619760LA01HU at dilution of 1:100 and Cy3-congugated Goat Anti-Rabbit IgG
KLF1 Antibodies
KLF1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005718 | KLF1 Antibody | Human | ELISA |
| CSB-PA619760LA01HU | KLF1 Antibody | Human | ELISA, IF |
| CSB-PA619760LB01HU | KLF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA619760LD01HU | KLF1 Antibody, Biotin conjugated | Human | ELISA |
KLF1 Proteins
KLF1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP619760HU CSB-EP619760HU CSB-BP619760HU CSB-MP619760HU CSB-EP619760HU-B |
Recombinant Human Krueppel-like factor 1 (KLF1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP619760HUa6 | Recombinant Human Krueppel-like factor 1 (KLF1) | E.coli |
