ITGB4
整合素β4（ITGB4）是整合素家族成員，與α6亞基結(jié)合形成α6β4復(fù)合物，在細(xì)胞黏附和信號(hào)轉(zhuǎn)導(dǎo)中起關(guān)鍵作用。ITGB4也被稱為CD104，主要分布于上皮細(xì)胞半橋粒結(jié)構(gòu)，負(fù)責(zé)錨定細(xì)胞與基底膜間的連接。ITGB4可通過激活PI3K和Ras通路參與細(xì)胞遷移及生存調(diào)控，其異常表達(dá)與多種侵襲性腫瘤密切相關(guān)，如三陰性乳腺癌、胰腺癌中常出現(xiàn)ITGB4過表達(dá)，促進(jìn)腫瘤轉(zhuǎn)移和耐藥性產(chǎn)生。ITGB4基因突變會(huì)導(dǎo)致交界型大皰性表皮松解癥，患者皮膚出現(xiàn)嚴(yán)重水皰病變。近年來針對該蛋白的藥物開發(fā)聚焦于單克隆抗體和肽類抑制劑，已有抗ITGB4人源化抗體（如ASC-06）進(jìn)入臨床前研究，擬用于抑制腫瘤細(xì)胞侵襲。另有研究探索其與EGFR抑制劑聯(lián)用方案，旨在突破現(xiàn)有靶向治療的耐藥瓶頸。
熱銷產(chǎn)品
Recombinant Human Integrin beta-4 (ITGB4), partial (CSB-EP011887HU3)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGB4 Recombinant Monoclonal Antibody (CSB-RA011887MA1HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing A549 cells surface stained with CSB-RA011887MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
ITGB4 Antibodies
ITGB4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011887GA01HU | ITGB4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA111732 | Phospho-ITGB4 (Tyr1510) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA254864 | ITGB4 (Ab-1510) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003051 | ITGB4 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA005846 | ITGB4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA011274 | Phospho-ITGB4 (Y1510) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011887LA01HU | ITGB4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA011887LC01HU | ITGB4 Antibody, FITC conjugated | Human | |
| CSB-PA011887LD01HU | ITGB4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011887MA1HU | ITGB4 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ITGB4 Proteins
ITGB4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011887HU CSB-EP011887HU CSB-BP011887HU CSB-MP011887HU CSB-EP011887HU-B |
Recombinant Human Integrin beta-4 (ITGB4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011887HU3 | Recombinant Human Integrin beta-4 (ITGB4), partial | E.coli |
ITGB4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011887MO CSB-EP011887MO CSB-BP011887MO CSB-MP011887MO CSB-EP011887MO-B |
Recombinant Mouse Integrin beta-4 (Itgb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP727354RA CSB-EP727354RA CSB-BP727354RA CSB-MP727354RA CSB-EP727354RA-B |
Recombinant Rat Integrin beta-4 (Itgb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF727354RAa2 | Recombinant Rat Integrin beta-4 (Itgb4), partial | in vitro E.coli expression system |
| CSB-CF727354RA | Recombinant Rat Integrin beta-4 (Itgb4), partial | in vitro E.coli expression system |
