ITGB4
整合素β4（ITGB4）是整合素家族成員，與α6亞基結合形成α6β4復合物，在細胞黏附和信號轉導中起關鍵作用。ITGB4也被稱為CD104，主要分布于上皮細胞半橋粒結構，負責錨定細胞與基底膜間的連接。ITGB4可通過激活PI3K和Ras通路參與細胞遷移及生存調控，其異常表達與多種侵襲性腫瘤密切相關，如三陰性乳腺癌、胰腺癌中常出現ITGB4過表達，促進腫瘤轉移和耐藥性產生。ITGB4基因突變會導致交界型大皰性表皮松解癥，患者皮膚出現嚴重水皰病變。近年來針對該蛋白的藥物開發聚焦于單克隆抗體和肽類抑制劑，已有抗ITGB4人源化抗體（如ASC-06）進入臨床前研究，擬用于抑制腫瘤細胞侵襲。另有研究探索其與EGFR抑制劑聯用方案，旨在突破現有靶向治療的耐藥瓶頸。
熱銷產品
Recombinant Human Integrin beta-4 (ITGB4), partial (CSB-EP011887HU3)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGB4 Recombinant Monoclonal Antibody (CSB-RA011887MA1HU)
驗證數據
Overlay Peak curve showing A549 cells surface stained with CSB-RA011887MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
ITGB4 Antibodies
ITGB4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011887GA01HU | ITGB4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA111732 | Phospho-ITGB4 (Tyr1510) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA254864 | ITGB4 (Ab-1510) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003051 | ITGB4 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA005846 | ITGB4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA011274 | Phospho-ITGB4 (Y1510) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011887LA01HU | ITGB4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA011887LC01HU | ITGB4 Antibody, FITC conjugated | Human | |
| CSB-PA011887LD01HU | ITGB4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011887MA1HU | ITGB4 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ITGB4 Proteins
ITGB4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011887HU CSB-EP011887HU CSB-BP011887HU CSB-MP011887HU CSB-EP011887HU-B |
Recombinant Human Integrin beta-4 (ITGB4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011887HU3 | Recombinant Human Integrin beta-4 (ITGB4), partial | E.coli |
ITGB4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011887MO CSB-EP011887MO CSB-BP011887MO CSB-MP011887MO CSB-EP011887MO-B |
Recombinant Mouse Integrin beta-4 (Itgb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP727354RA CSB-EP727354RA CSB-BP727354RA CSB-MP727354RA CSB-EP727354RA-B |
Recombinant Rat Integrin beta-4 (Itgb4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF727354RAa2 | Recombinant Rat Integrin beta-4 (Itgb4), partial | in vitro E.coli expression system |
| CSB-CF727354RA | Recombinant Rat Integrin beta-4 (Itgb4), partial | in vitro E.coli expression system |
