ITGAV

整合素αV（ITGAV），也稱為CD51或VTNR，是一類廣泛分布于細(xì)胞表面的跨膜受體蛋白，通過與β亞基結(jié)合形成異二聚體，參與調(diào)控細(xì)胞與細(xì)胞外基質(zhì)的相互作用。該蛋白在胚胎發(fā)育、組織修復(fù)及免疫調(diào)節(jié)等生理過程中發(fā)揮關(guān)鍵作用，尤其在腫瘤侵襲轉(zhuǎn)移、血管生成和纖維化疾病中備受關(guān)注。研究表明，ITGAV異常表達(dá)與多種惡性腫瘤（如膠質(zhì)母細(xì)胞瘤、乳腺癌）、器官纖維化（肺、肝）及骨代謝疾病密切相關(guān)，其功能失調(diào)可導(dǎo)致細(xì)胞黏附異常和微環(huán)境重塑。
近年來，靶向ITGAV的藥物研發(fā)進(jìn)展顯著。例如，抑制劑Cilengitide通過阻斷αVβ3和αVβ5整合素活性，曾進(jìn)入晚期膠質(zhì)瘤的III期臨床試驗(yàn)，但因療效未達(dá)預(yù)期而終止。當(dāng)前研究聚焦于開發(fā)新型小分子拮抗劑和抗體藥物，探索其在抗腫瘤血管生成、抑制轉(zhuǎn)移及纖維化治療中的潛力。此外，ITGAV與免疫檢查點(diǎn)分子的協(xié)同作用也為聯(lián)合療法提供了新方向，部分候選藥物已進(jìn)入早期臨床評估階段。

熱銷產(chǎn)品

Recombinant Human ITGAV&ITGB6 Heterodimer Protein (Active) (CSB-MP6145HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Human TGFB1 (CSB-MP023446HU(A4)c9). The EC₅₀ is 8.576-10.18 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Anti-ITGB6 recombinant antibody (CSB-RA011890MA1HU). The EC₅₀ is 7.021-9.054 ng/mL.

The purity of ITGAV&ITGB6 was greater than 90% as determined by SEC-HPLC

ITGAV Recombinant Monoclonal Antibody (CSB-RA279866A0HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
All lanes: ITGAV antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 113, 112 kDa
Observed band size: 130 kDa

IHC image of CSB-RA279866A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ITGAV Antibody

ITGAV Protein

ITGAV Antibodies

ITGAV for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA000074	Cleaved-ITGAV (K889) Antibody	Human	WB, ELISA
CSB-PA003047	ITGAV Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA011877LA01HU	ITGAV Antibody	Human	ELISA, WB, IHC, IF
CSB-PA011877LB01HU	ITGAV Antibody, HRP conjugated	Human	ELISA
CSB-PA011877LC01HU	ITGAV Antibody, FITC conjugated	Human
CSB-PA011877LD01HU	ITGAV Antibody, Biotin conjugated	Human	ELISA
CSB-RA548303A0HU	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA279866A0HU	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA011877MA1HU	ITGAV Recombinant Monoclonal Antibody	Human, Mouse	ELISA, IF, FC

ITGAV Proteins

ITGAV Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011877BO CSB-EP011877BO CSB-BP011877BO CSB-MP011877BO CSB-EP011877BO-B	Recombinant Bovine Integrin alpha-V (ITGAV), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGAV Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011877MO CSB-EP011877MO CSB-BP011877MO CSB-EP011877MO-B	Recombinant Mouse Integrin alpha-V (Itgav), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

ITGAV Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011877CH CSB-EP011877CH CSB-BP011877CH CSB-MP011877CH CSB-EP011877CH-B	Recombinant Chicken Integrin alpha-V (ITGAV), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGAV Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP011877HU	Recombinant Human Integrin alpha-V (ITGAV), partial	Yeast
CSB-EP011877HU CSB-BP011877HU CSB-EP011877HU-B	Recombinant Human Integrin alpha-V (ITGAV), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli