ITGAL
ITGAL對(duì)應(yīng)的蛋白全稱為整合素αL，也被稱為CD11a或LFA-1α，常與β2亞基結(jié)合形成淋巴細(xì)胞功能相關(guān)抗原-1（LFA-1）。這種蛋白在免疫細(xì)胞表面廣泛表達(dá)，尤其在T細(xì)胞和中性粒細(xì)胞中活躍，通過(guò)介導(dǎo)細(xì)胞間黏附參與炎癥反應(yīng)、免疫細(xì)胞遷移及抗原提呈等過(guò)程。其功能異常常與自身免疫疾病相關(guān)，例如多發(fā)性硬化癥、類風(fēng)濕性關(guān)節(jié)炎患者的LFA-1活性異常升高，導(dǎo)致免疫細(xì)胞過(guò)度攻擊自身組織。此外，該蛋白在器官移植排斥反應(yīng)和某些白血病中也顯示出調(diào)控作用。
近年來(lái)，針對(duì)LFA-1的抑制劑成為藥物開(kāi)發(fā)熱點(diǎn)。早期單抗藥物如奧法木單抗曾用于治療復(fù)發(fā)型多發(fā)性硬化，但因療效局限逐漸淡出。小分子拮抗劑如BMS-817399在動(dòng)物模型中顯示出抑制炎癥浸潤(rùn)潛力，目前處于臨床前研究階段。部分藥物因阻斷LFA-1可能引發(fā)感染風(fēng)險(xiǎn)，研究者正探索局部給藥或變構(gòu)調(diào)節(jié)策略以平衡療效與安全性。在腫瘤免疫領(lǐng)域，聯(lián)合LFA-1調(diào)控與其他免疫檢查點(diǎn)抑制劑的方案也進(jìn)入早期探索。
熱銷產(chǎn)品
Recombinant Human Integrin alpha-L (ITGAL), partial (CSB-MP011875HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of ITGAL was greater than 90% as determined by SEC-HPLC
ITGAL Recombinant Monoclonal Antibody (CSB-RA787996A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: ITGAL antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 129, 135, 120 kDa
Observed band size: 130 kDa
Immunofluorescence staining of THP-1 cell with CSB-RA787996A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 490-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ITGAL Antibodies
ITGAL for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011875LA01MO | Itgal Antibody | Mouse | ELISA |
ITGAL for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006157 | ITGAL Antibody | Human | WB, ELISA |
| CSB-PA932598 | ITGAL Antibody | Human | ELISA,IHC |
| CSB-PA011875LA01HU | ITGAL Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA011875LB01HU | ITGAL Antibody, HRP conjugated | Human | ELISA |
| CSB-RA787996A0HU | ITGAL Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
ITGAL Proteins
ITGAL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP011875HU CSB-EP011875HU-B |
Recombinant Human Integrin alpha-L (ITGAL), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | E.coli |
| CSB-YP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Yeast |
| CSB-MP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Mammalian cell |
ITGAL Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | Yeast |
| CSB-EP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | E.coli |
| CSB-BP011875MO CSB-MP011875MO CSB-EP011875MO-B |
Recombinant Mouse Integrin alpha-L (Itgal), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAL Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011875BO CSB-EP011875BO CSB-BP011875BO CSB-MP011875BO CSB-EP011875BO-B |
Recombinant Bovine Integrin alpha-L (ITGAL), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
