ITGA1
整合素α1（ITGA1）蛋白，全稱為整合素α1亞基，常被稱為CD49a或VLA-1，與β1亞基結(jié)合形成α1β1整合素受體。這一受體廣泛分布于成纖維細胞、免疫細胞及內(nèi)皮細胞表面，通過識別細胞外基質(zhì)中的膠原和層粘連蛋白，介導(dǎo)細胞與周圍環(huán)境的動態(tài)交互，調(diào)控組織重塑、炎癥反應(yīng)和血管生成。在病理狀態(tài)下，α1β1整合素活性異常與多種纖維化疾病密切相關(guān)，例如特發(fā)性肺纖維化和肝纖維化中，其過度激活會加速膠原沉積，導(dǎo)致器官功能衰竭。此外，ITGA1在腫瘤微環(huán)境中通過增強癌細胞黏附和侵襲能力，與乳腺癌、黑色素瘤的轉(zhuǎn)移潛能相關(guān)聯(lián)。藥物研發(fā)領(lǐng)域，早期針對整合素家族的廣譜抑制劑因脫靶效應(yīng)受限，近年轉(zhuǎn)向開發(fā)亞基特異性靶點。針對α1的小分子拮抗劑已在動物模型中顯示抑制纖維化進展的潛力，而單克隆抗體類藥物處于臨床前優(yōu)化階段，未來或為抗纖維化及抗癌治療提供新策略。
熱銷產(chǎn)品
ITGA1 Antibody (CSB-PA011861LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011861LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA011861LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Integrin alpha-1(ITGA1) ELISA kit (CSB-EL011861HU)
驗證數(shù)據(jù)
貨號：CSB-EL011861HU
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ITGA1 Antibodies
ITGA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA345531 | ITGA1 Antibody | Human | IHC,ELISA |
| CSB-PA011861LA01HU | ITGA1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA011861LB01HU | ITGA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011861LC01HU | ITGA1 Antibody, FITC conjugated | Human | |
| CSB-PA011861LD01HU | ITGA1 Antibody, Biotin conjugated | Human | ELISA |
ITGA1 Proteins
ITGA1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011861RA CSB-EP011861RA CSB-BP011861RA CSB-MP011861RA CSB-EP011861RA-B |
Recombinant Rat Integrin alpha-1 (Itga1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011861HU CSB-EP011861HU CSB-BP011861HU CSB-MP011861HU CSB-EP011861HU-B |
Recombinant Human Integrin alpha-1 (ITGA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP666304MO CSB-EP666304MO CSB-BP666304MO CSB-MP666304MO CSB-EP666304MO-B |
Recombinant Mouse Integrin alpha-1 (Itga1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP835455CH CSB-EP835455CH CSB-BP835455CH CSB-MP835455CH CSB-EP835455CH-B |
Recombinant Chicken Integrin alpha-1 (ITGA1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA1 ELISA Kit
ITGA1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011861HU | Human Integrin alpha-1(ITGA1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
