IRF6
IRF6,全稱為干擾素調(diào)節(jié)因子6,別名為OFC6、VWS1等,屬于IRF家族成員。IRF6在面部結(jié)構(gòu)發(fā)育過(guò)程中發(fā)揮著關(guān)鍵作用,其表達(dá)缺失可能導(dǎo)致唇腭裂等發(fā)育異常。此外,IRF6還參與免疫細(xì)胞的調(diào)控,影響白細(xì)胞的發(fā)育和功能,并在促炎和抗炎反應(yīng)中起到調(diào)節(jié)作用。研究表明,IRF6通過(guò)結(jié)合目標(biāo)基因的啟動(dòng)子區(qū)域來(lái)調(diào)節(jié)基因轉(zhuǎn)錄,影響多種生物學(xué)過(guò)程,包括細(xì)胞遷移、粘附和信號(hào)傳遞。IRF6基因的多態(tài)性與非綜合征性唇腭裂密切相關(guān),其變異情況揭示了唇腭裂的復(fù)雜遺傳背景。
在藥物研發(fā)方面,IRF6已成為治療血管損傷后再狹窄的潛在靶點(diǎn)。一項(xiàng)專利顯示,IRF6基因敲除小鼠和野生型小鼠的實(shí)驗(yàn)結(jié)果表明,IRF6在血管損傷后再狹窄中發(fā)揮作用,提示其可作為藥物研發(fā)的靶點(diǎn)。此外,IRF6還與卵巢癌相關(guān),其在腫瘤組織中的RNA和蛋白水平高于正常樣本,為相關(guān)疾病的治療提供了新的思路。
熱銷產(chǎn)品
IRF6 Antibody (CSB-PA011821LA01HU)
驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: PC-3 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, , Mouse liver tissue
All lanes: IRF6 antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54, 42 kDa
Observed band size: 54 kDa

Immunofluorescent analysis of HepG2 cells using CSB-PA011821LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
IRF6 Antibodies
IRF6 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA287048 | IRF6 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA102246 | IRF6 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA011821LA01HU | IRF6 Antibody | Human, Mouse | ELISA, WB, IF |
CSB-PA011821LB01HU | IRF6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA011821LC01HU | IRF6 Antibody, FITC conjugated | Human | |
CSB-PA011821LD01HU | IRF6 Antibody, Biotin conjugated | Human | ELISA |
IRF6 Proteins
IRF6 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP011821HU CSB-EP011821HU CSB-BP011821HU CSB-MP011821HU CSB-EP011821HU-B |
Recombinant Human Interferon regulatory factor 6 (IRF6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |