IFNAR2
IFNAR2，全稱為干擾素α和β受體亞基2，是一種I型膜蛋白，與IFNAR1共同構成干擾素α和β受體的兩條鏈。該蛋白屬于II型細胞因子受體家族，其作用機制是通過與干擾素結合，激活JAK-STAT信號通路，進而磷酸化多種蛋白質，包括STAT1和STAT2，從而引發一系列細胞反應。IFNAR2在多種組織中表達，包括泌尿生殖系統、淋巴系統、肝臟和神經系統。IFNAR2與乙型肝炎和免疫缺陷45相關，其突變可能導致免疫缺陷疾病。目前，針對IFNAR2的藥物研發主要集中在利用其作為穩定劑來提高干擾素制劑的穩定性和效力，例如開發長效干擾素制劑。此外，IFNAR2也被用作治療自身免疫性疾病的靶點，例如阿斯利康的治療紅斑狼瘡新藥Saphnelo（anifrolumab）就是一種I型干擾素拮抗劑，可與IFNAR2結合，拮抗所有I型干擾素的相關活性。
熱銷產品
Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial (CSB-MP011047HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of IFNAR2 was greater than 95% as determined by SEC-HPLC
IFNAR2 Antibody (CSB-PA011047ESR2HU)
驗證數據
Western blot
All lanes: IFNAR2 antibody at 10µg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 58, 38, 28 kDa
Observed band size: 58 kDa
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA011047ESR2HU at dilution of 1:100
IFNAR2 Antibodies
IFNAR2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011047GA01HU | IFNAR2 Antibody | Human | ELISA,WB |
| CSB-PA011047ESR1HU | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA011047ESR2HU | IFNAR2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA11439A0Rb | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA11439D0Rb | IFNAR2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005590 | IFNAR2 Antibody | Human | WB, ELISA |
IFNAR2 Proteins
IFNAR2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011047HU CSB-BP011047HU CSB-EP011047HU-B |
Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011047HU | Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2), partial | E.coli |
| CSB-CF011047HU(A4) | Recombinant Human Interferon alpha/beta receptor 2 (IFNAR2) | in vitro E.coli expression system |
IFNAR2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011047MO | Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial | Yeast |
| CSB-EP011047MO CSB-BP011047MO CSB-MP011047MO CSB-EP011047MO-B |
Recombinant Mouse Interferon alpha/beta receptor 2 (Ifnar2), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP850133SH CSB-EP850133SH CSB-BP850133SH CSB-MP850133SH CSB-EP850133SH-B |
Recombinant Sheep Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP856764BO CSB-EP856764BO CSB-BP856764BO CSB-MP856764BO CSB-EP856764BO-B |
Recombinant Bovine Interferon alpha/beta receptor 2 (IFNAR2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNAR2 ELISA Kit
IFNAR2 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011047HU | Human Interferon alpha/beta receptor 2(IFNAR2) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/ml |
