IFNA2
IFNA2（干擾素-α2）是干擾素-α（IFN-α）家族成員之一，具有抗病毒、抗腫瘤和免疫調(diào)節(jié)功能。它是一種由約165-166個(gè)氨基酸殘基組成的蛋白質(zhì)，分子量約18-21 kDa，具有α-螺旋和β-折疊結(jié)構(gòu)域。IFNA2基因位于人類染色體9上，與其他IFN-α亞型基因聚集。其主要功能包括激活細(xì)胞內(nèi)抗病毒防御機(jī)制、抑制腫瘤細(xì)胞增殖、促進(jìn)腫瘤細(xì)胞凋亡以及增強(qiáng)免疫細(xì)胞活性。IFNA2通過與其受體結(jié)合，激活JAK-STAT信號(hào)通路，進(jìn)而磷酸化STAT蛋白，導(dǎo)致它們二聚化并轉(zhuǎn)移到細(xì)胞核中，調(diào)控干擾素刺激基因（ISGs）的表達(dá)。此外，IFNA2還涉及PI3K-AKT和MAPK信號(hào)通路，參與細(xì)胞生存、增殖、分化和凋亡等過程。臨床上，IFNA2被用于治療乙型和丙型肝炎以及某些類型的癌癥，盡管治療效果可能受到個(gè)體差異、病毒抗性和副作用的影響。
熱銷產(chǎn)品
Recombinant Human Interferon alpha-2 (IFNA2) (Active) (CSB-MP360706HU)
驗(yàn)證數(shù)據(jù)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IFNA2 at 2 μg/ml can bind Human IFNAR2(CSB-MP011047HU). The EC50 is 154.2-191.9 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IFNA2 at 2 μg/ml can bind Anti-IFNA2 recombinant antibody(CSB-RA360706MA2HU). The EC50 is 2.366-2.818 ng/mL.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Recombinant Human Interferon alpha-2 (IFNA2) (CSB-EP360706HUe3)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IFNA2 Antibodies
IFNA2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06504D0Rb | IFNA2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA06504B0Rb | IFNA2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06504A0Rb | IFNA2 Antibody | Human, Mouse | ELISA,WB? |
| CSB-PA250552 | IFNA2 Antibody | Human | ELISA,IHC |
| CSB-PA048892 | IFNA2 Antibody | Human | ELISA,IHC |
IFNA2 Proteins
IFNA2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP360706HU | Recombinant Human Interferon alpha-2 (IFNA2) | Yeast |
| CSB-EP360706HU | Recombinant Human Interferon alpha-2 (IFNA2) | E.coli |
| CSB-AP002761HU | Recombinant Human Interferon alpha-2 protein (IFNA2) | Yeast |
| CSB-AP002771HU | Recombinant Human Interferon alpha-2 protein (IFNA2), partial (Active) | E.Coli |
| CSB-AP002781HU | Recombinant Human Interferon alpha-2 protein (IFNA2) | Yeast |
| CSB-BP360706HU CSB-EP360706HU-B |
Recombinant Human Interferon alpha-2 (IFNA2) | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP004191HU | Recombinant Human Interferon alpha-2 (IFNA2) (Active) | E.coli |
| CSB-EP360706HUe3 | Recombinant Human Interferon alpha-2 (IFNA2) | E.coli |
| CSB-MP360706HU | Recombinant Human Interferon alpha-2 (IFNA2) (Active) | Mammalian cell |
| CSB-MP360706HU-WD | Recombinant Human Interferon alpha-2 (IFNA2) (Active) | Mammalian cell |
IFNA2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP365593MO CSB-BP365593MO CSB-EP365593MO-B |
Recombinant Mouse Interferon alpha-2 (Ifna2) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
IFNA2 ELISA Kit
IFNA2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011038HU | Human interferon alpha-2(IFNA2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 7.8 pg/ml. |
IFNA2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011038MO | Mouse interferon alpha-2(IFNA2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 2.35 pg/mL |
