HSPA1A
HSPA1A，全稱為熱休克蛋白家族A成員1A（Heat Shock Protein Family A Member 1A），是一種重要的分子伴侶，在細(xì)胞應(yīng)激反應(yīng)中發(fā)揮著關(guān)鍵作用。它能夠幫助蛋白質(zhì)正確折疊，修復(fù)錯(cuò)誤折疊的蛋白質(zhì)，并促進(jìn)蛋白質(zhì)復(fù)合物的形成與解離，從而維護(hù)蛋白質(zhì)組的完整性。HSPA1A蛋白也參與了細(xì)胞內(nèi)的信號(hào)傳導(dǎo)過(guò)程，影響細(xì)胞的生長(zhǎng)、分化和凋亡。
HSPA1A蛋白的表達(dá)水平與多種疾病相關(guān)，如癌癥、神經(jīng)退行性疾病和感染性疾病等。近年來(lái)，HSPA1A蛋白成為藥物研發(fā)的一個(gè)熱點(diǎn)，研究人員正在探索其作為治療癌癥、神經(jīng)退行性疾病和感染性疾病的潛在靶點(diǎn)。例如，有研究顯示，HSPA1A蛋白可以抑制腫瘤細(xì)胞的增殖和轉(zhuǎn)移，并促進(jìn)腫瘤細(xì)胞的凋亡。此外，HSPA1A蛋白還可以增強(qiáng)免疫細(xì)胞的功能，幫助身體抵抗感染。因此，HSPA1A蛋白有望成為開(kāi)發(fā)新型抗癌藥物和治療感染性疾病的潛在靶點(diǎn)。
熱銷產(chǎn)品
HSPA1A/HSPA1B Recombinant Monoclonal Antibody (CSB-RA151186A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HEK293 whole cell lysate(30μg), U937 whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg)
All lanes: Hsp70 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
Exposure time: 3min
IHC image of CSB-RA151186A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing Hela cells stained with CSB-RA151186A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Heat Shock Protein 72(HSP-72) ELISA Kit (CSB-E14916h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E14916h
規(guī)格：96T/48T
靈敏度：0.78 ng/mL
檢測(cè)范圍：3.12 ng/mL-200 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
HSPA1A Antibodies
HSPA1A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA01082GA01HU | HSPA1A Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA556911 | HSPA1A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA137102 | HSPA1A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA10899A0Rb | HSPA1A Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA10899B0Rb | HSPA1A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10899C0Rb | HSPA1A Antibody, FITC conjugated | Human | |
| CSB-PA10899D0Rb | HSPA1A Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA357302LA01HU | HSPA1A Antibody | Human | ELISA, WB, IHC |
| CSB-PA357302LB01HU | HSPA1A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA357302LC01HU | HSPA1A Antibody, FITC conjugated | Human | |
| CSB-PA357302LD01HU | HSPA1A Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA357302A0m | HSPA1A Monoclonal Antibody | Human | ELISA, WB |
HSPA1A ELISA Kit
HSPA1A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14916h | Human Heat Shock Protein 72(HSP-72) ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 0.78 ng/mL |
