HSF1
HSF1，即熱休克轉(zhuǎn)錄因子1，也稱為HSTF1，是一種轉(zhuǎn)錄因子，在溫度脅迫后被迅速誘導，能夠結合熱休克啟動子元件（HSE）。這種蛋白質(zhì)在調(diào)節(jié)壽命方面發(fā)揮作用，其表達受到磷酸化的抑制，磷酸化促進熱休克蛋白90的結合。HSF1是細胞熱休克蛋白（HSP）表達的主要調(diào)控因子，在不同物種中高度保守。
HSF1在應激反應中能啟動基因的轉(zhuǎn)錄過程，促進HSPs的表達，發(fā)揮耐受不良刺激、保持細胞完整性、減輕炎癥和參與免疫等重要適應性保護作用。
HSF1還能直接或間接調(diào)節(jié)許多非熱休克基因的表達，在正常的發(fā)育過程或病理事件中具有不依賴熱休克或其他細胞應激的重要功能。
熱銷產(chǎn)品
HSF1 Recombinant Monoclonal Antibody (CSB-RA279005A0HU)
驗證數(shù)據(jù)
IHC image of CSB-RA279005A0HU diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA279005A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
HSF1 Antibodies
HSF1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA010791GA01HU | HSF1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA966483 | Phospho-HSF1 (Ser307) Antibody | Human | ELISA,WB,IF |
| CSB-PA049595 | Phospho-HSF1 (Ser303) Antibody | Human | ELISA,WB,IHC |
| CSB-PA167700 | HSF1 (Ab-307) Antibody | Human | ELISA,WB,IHC |
| CSB-PA796250 | HSF1 (Ab-303) Antibody | Human | ELISA,WB,IHC |
| CSB-PA829409 | Phospho-HSF1 (Thr142) Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA268961 | HSF1 (Ab-142) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA616169 | HSF1 (Ab-121) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002974 | HSF1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA009282 | Phospho-HSF1 (S303) Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA009285 | Phospho-HSF1 (S121) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA009287 | Phospho-HSF1 (T142) Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA009288 | Phospho-HSF1 (S307) Antibody | Human | WB, IF, ELISA |
| CSB-PA009292 | HSF1 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA009295 | HSF1 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA009299 | HSF1 Antibody | Human | WB, ELISA |
| CSB-PA225962 | HSF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA249679 | HSF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA010791LA01HU | HSF1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA010791LB01HU | HSF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010791LC01HU | HSF1 Antibody, FITC conjugated | Human | |
| CSB-PA010791LD01HU | HSF1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA010791A326phHU | Phospho-HSF1 (S326) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA279005A0HU | HSF1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
