HEPACAM
HEPACAM，全稱為肝細胞和星形膠質(zhì)細胞粘附分子，是一種廣泛表達于多種組織中的跨膜蛋白。該蛋白常見別名包括Hepatocellular Adhesion Molecule和Mucin-18等。HEPACAM主要通過與其他細胞表面分子相互作用，參與細胞粘附、遷移和信號傳導(dǎo)等過程。在腫瘤發(fā)生發(fā)展中，HEPACAM的表達異常與多種癌癥的侵襲和轉(zhuǎn)移密切相關(guān)。此外，該蛋白還與神經(jīng)系統(tǒng)疾病、心血管疾病等非腫瘤性疾病有關(guān)。近年來，針對HEPACAM的藥物研發(fā)取得了一定進展，如義翹神州和MCE公司分別開發(fā)了重組人HEPACAM蛋白和HEPACAM蛋白（Human, HEK293, His），用于細胞運動和腫瘤生長抑制等研究。賽業(yè)生物則構(gòu)建了Hepacam基因敲除小鼠模型，用于研究該基因在腫瘤抑制中的作用。隨著研究的深入，HEPACAM有望成為疾病診斷和治療的新的靶點。
熱銷產(chǎn)品
HEPACAM Antibody (CSB-PA010287LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: HEPACAM antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 41 kDa
Observed band size: 47 kDa
Immunofluorescence staining of MCF-7 cells with CSB-PA010287LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
HEPACAM Antibodies
HEPACAM for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010287GA01HU | HEPACAM Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA010287LA01HU | HEPACAM Antibody | Human | ELISA, WB, IF |
| CSB-PA010287LB01HU | HEPACAM Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010287LC01HU | HEPACAM Antibody, FITC conjugated | Human | |
| CSB-PA010287LD01HU | HEPACAM Antibody, Biotin conjugated | Human | ELISA |
HEPACAM Proteins
HEPACAM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010287HU CSB-EP010287HU CSB-BP010287HU CSB-MP010287HU CSB-EP010287HU-B |
Recombinant Human Hepatocyte cell adhesion molecule (HEPACAM), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
