HCN1
HCN1，即超極化激活型環核苷酸門控通道1，別名If、Ih、HCN1等。它是一種由HCN1基因編碼的膜蛋白，屬于超極化激活型環核苷酸門控通道家族成員，在心臟和大腦等組織中表達。HCN1的作用機制是在細胞膜超極化時激活，允許鈉和鉀離子通過，對心臟節律和神經元興奮性具有調節作用。HCN1參與了心臟的自主節律控制和心臟起搏，同時在神經系統中調節神經元的發放頻率和信號傳遞。HCN1的功能異常與心臟疾病中的竇性心動過緩、長QT綜合征，以及神經系統疾病中的癲癇有關，是心臟學和神經生物學研究中的一個重要分子靶點。
熱銷產品
HCN1 Antibody (CSB-PA010216LA01HU)
驗證數據
IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA010216LA01HU diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA010216LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
HCN1 Antibodies
HCN1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA202569 | HCN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA409812 | HCN1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA010216LA01HU | HCN1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA010216LB01HU | HCN1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010216LC01HU | HCN1 Antibody, FITC conjugated | Human | |
| CSB-PA010216LD01HU | HCN1 Antibody, Biotin conjugated | Human | ELISA |
HCN1 Proteins
HCN1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP010216HU CSB-EP010216HU CSB-BP010216HU CSB-MP010216HU CSB-EP010216HU-B |
Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
