GZMB

GZMB，即顆粒酶B，別名CCPI、CGL-1、CSP-B、CGL1、CTSGL1、HLP、SECT。GZMB是一種由細(xì)胞毒性T細(xì)胞（CTLs）和自然殺傷細(xì)胞（NK細(xì)胞）產(chǎn)生的絲氨酸蛋白酶，屬于細(xì)胞毒性淋巴細(xì)胞顆粒中的酶類。GZMB的作用機(jī)制包括其在細(xì)胞外環(huán)境中的作用，如導(dǎo)致炎癥、血管功能障礙和通透性、細(xì)胞粘附減少、基質(zhì)隔離生長(zhǎng)因子的釋放、受體激活和細(xì)胞外基質(zhì)裂解。GZMB在多種病理狀態(tài)下發(fā)揮作用，包括心血管疾病、自身免疫性疾病、腫瘤免疫逃逸等。GZMB不僅參與細(xì)胞凋亡過程，還與炎癥反應(yīng)、組織重塑和腫瘤免疫監(jiān)視有關(guān)。GZMB的活性受到嚴(yán)格調(diào)控，其異常表達(dá)與多種疾病的發(fā)生發(fā)展相關(guān)，是一個(gè)有潛力的治療靶點(diǎn)和生物標(biāo)志物。

熱銷產(chǎn)品

Recombinant Human Granzyme B (GZMB) (CSB-EP010082HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GZMB Recombinant Monoclonal Antibody (CSB-RA010082MA1HU)

驗(yàn)證數(shù)據(jù)

Western Blot Positive WB detected in:K562 whole cell lysate (20μg) All lanes: GZMB antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size:27.7 kDa Observed band size:28 kDa Exposure time:300s

IHC?image?of?CSB-RA010082MA1HU?diluted?at?1:50?and?staining?in?paraffin-embedded?human?tonsil tissue?performed?on?a?Leica?BondTM?system.?After?dewaxing?and?hydration,?antigen?retrieval?was?mediated?by?high?pressure?in?a?citrate?buffer?(pH?6.0).?Section?was?blocked?with?10%?normal?goat?serum?30min?at?RT.?Then?primary?antibody?(1%?BSA)?was?incubated?at?4°C?overnight.?The?primary?is?detected?by?a?Goat?anti-Mouse?IgG?labeled?by?HRP?and?visualized?using?0.05%?DAB.

Overlay Peak curve showing THP-1 cells stained with CSB-RA010082MA1HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

GZMB Antibody

GZMB Protein

GZMB ELISA Kit

GZMB Antibodies

GZMB for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA010082GA01HU	GZMB Antibody	Human	ELISA,WB,IHC,IF
CSB-PA010082LC01HU	GZMB Antibody, FITC conjugated	Human
CSB-PA010082LA01HU	GZMB Antibody	Human	ELISA, IHC, IF
CSB-PA272248	GZMB Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA108047	GZMB Antibody	Human	ELISA,IHC
CSB-PA986806	GZMB Antibody	Human	ELISA,IHC
CSB-RA794900A0HU	GZMB Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF
CSB-RA010082MA1HU	GZMB Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC

GZMB Proteins

GZMB Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP010082HU	Recombinant Human Granzyme B (GZMB)	Yeast
CSB-EP010082HU	Recombinant Human Granzyme B (GZMB)	E.coli
CSB-BP010082HU CSB-MP010082HU CSB-EP010082HU-B	Recombinant Human Granzyme B (GZMB)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010082HUa6	Recombinant Human Granzyme B (GZMB)	E.coli

GZMB Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP010082RA CSB-EP010082RA CSB-BP010082RA CSB-MP010082RA CSB-EP010082RA-B	Recombinant Rat Granzyme B (Gzmb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GZMB Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP010082MO CSB-EP010082MO CSB-BP010082MO CSB-MP010082MO CSB-EP010082MO-B	Recombinant Mouse Granzyme B (G,H) (Gzmb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli