GZMB

GZMB，即顆粒酶B，別名CCPI、CGL-1、CSP-B、CGL1、CTSGL1、HLP、SECT。GZMB是一種由細胞毒性T細胞（CTLs）和自然殺傷細胞（NK細胞）產生的絲氨酸蛋白酶，屬于細胞毒性淋巴細胞顆粒中的酶類。GZMB的作用機制包括其在細胞外環境中的作用，如導致炎癥、血管功能障礙和通透性、細胞粘附減少、基質隔離生長因子的釋放、受體激活和細胞外基質裂解。GZMB在多種病理狀態下發揮作用，包括心血管疾病、自身免疫性疾病、腫瘤免疫逃逸等。GZMB不僅參與細胞凋亡過程，還與炎癥反應、組織重塑和腫瘤免疫監視有關。GZMB的活性受到嚴格調控，其異常表達與多種疾病的發生發展相關，是一個有潛力的治療靶點和生物標志物。

熱銷產品

Recombinant Human Granzyme B (GZMB) (CSB-EP010082HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GZMB Recombinant Monoclonal Antibody (CSB-RA010082MA1HU)

驗證數據

Western Blot Positive WB detected in:K562 whole cell lysate (20μg) All lanes: GZMB antibody at 1:1000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size:27.7 kDa Observed band size:28 kDa Exposure time:300s

IHC image of CSB-RA010082MA1HU diluted at 1:50 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

Overlay Peak curve showing THP-1 cells stained with CSB-RA010082MA1HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

GZMB Antibody

GZMB Protein

GZMB ELISA Kit

GZMB Antibodies

GZMB for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA010082GA01HU	GZMB Antibody	Human	ELISA,WB,IHC,IF
CSB-PA010082LC01HU	GZMB Antibody, FITC conjugated	Human
CSB-PA010082LA01HU	GZMB Antibody	Human	ELISA, IHC, IF
CSB-PA272248	GZMB Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA108047	GZMB Antibody	Human	ELISA,IHC
CSB-PA986806	GZMB Antibody	Human	ELISA,IHC
CSB-RA794900A0HU	GZMB Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF
CSB-RA010082MA1HU	GZMB Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC

GZMB Proteins

GZMB Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP010082HU	Recombinant Human Granzyme B (GZMB)	Yeast
CSB-EP010082HU	Recombinant Human Granzyme B (GZMB)	E.coli
CSB-BP010082HU CSB-MP010082HU CSB-EP010082HU-B	Recombinant Human Granzyme B (GZMB)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP010082HUa6	Recombinant Human Granzyme B (GZMB)	E.coli

GZMB Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP010082RA CSB-EP010082RA CSB-BP010082RA CSB-MP010082RA CSB-EP010082RA-B	Recombinant Rat Granzyme B (Gzmb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GZMB Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP010082MO CSB-EP010082MO CSB-BP010082MO CSB-MP010082MO CSB-EP010082MO-B	Recombinant Mouse Granzyme B (G,H) (Gzmb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli