GRM2
GRM2，即代謝型谷氨酸受體2，別名GPRC1B、mGlu2、MGLUR2等。它是一種G蛋白偶聯(lián)受體(GPCR)，主要在神經(jīng)元和肌肉細(xì)胞上表達。GRM2的作用機制是通過與特定的配體結(jié)合，激活細(xì)胞內(nèi)的信號轉(zhuǎn)導(dǎo)通路，影響細(xì)胞內(nèi)的生理過程。配體結(jié)合導(dǎo)致GRM2發(fā)生構(gòu)象變化，進而觸發(fā)通過鳥苷酸結(jié)合蛋白（G蛋白）的信號傳導(dǎo)，并調(diào)節(jié)下游效應(yīng)因子，如腺苷酸環(huán)化酶的活性。GRM2的信號傳導(dǎo)抑制了腺苷酸環(huán)化酶活性，可能參與調(diào)節(jié)神經(jīng)傳導(dǎo)的抑制或與突觸形成及突觸穩(wěn)定有關(guān)。GRM2在生物學(xué)上的意義非常重要，它不僅在神經(jīng)系統(tǒng)中發(fā)揮關(guān)鍵作用，調(diào)節(jié)突觸傳遞和海馬功能，還涉及到多種神經(jīng)病理狀態(tài)，包括神經(jīng)退行性疾病和精神疾病。GRM2的表達在成年海馬齒狀顆粒細(xì)胞中特別高，對成年海馬中新生齒狀顆粒細(xì)胞的發(fā)育和功能整合至關(guān)重要。此外，GRM2還通過調(diào)節(jié)MEK/ERK1/2信號通路的磷酸化和激活狀態(tài)，影響神經(jīng)元的發(fā)育。GRM2的功能異常與多種腦部疾病的發(fā)生發(fā)展有關(guān)，因此，它也是藥物開發(fā)和神經(jīng)科學(xué)研究的重要靶點。
熱銷產(chǎn)品
GRM2 Antibody (CSB-PA621775LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat heart tissue
All lanes: GRM2 antibody at 5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 96 kDa
Observed band size: 96 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA621775LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
GRM2 Antibodies
GRM2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009932GA01HU | GRM2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA009020 | GRM2 Antibody | Human,Mouse,Rat | IHC, IF, ELISA |
| CSB-PA621775LA01HU | GRM2 Antibody | Human, Rat | ELISA, WB, IF |
| CSB-PA621775LC01HU | GRM2 Antibody, FITC conjugated | Human | |
| CSB-PA621775LD01HU | GRM2 Antibody, Biotin conjugated | Human | ELISA |
GRM2 Proteins
GRM2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP009932RA CSB-EP009932RA CSB-BP009932RA CSB-MP009932RA CSB-EP009932RA-B |
Recombinant Rat Metabotropic glutamate receptor 2 (Grm2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP621775HU CSB-EP621775HU CSB-BP621775HU CSB-MP621775HU CSB-EP621775HU-B |
Recombinant Human Metabotropic glutamate receptor 2 (GRM2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GRM2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP621804MO CSB-EP621804MO CSB-BP621804MO CSB-MP621804MO CSB-EP621804MO-B |
Recombinant Mouse Metabotropic glutamate receptor 2 (Grm2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
