GAD1
GAD1，即谷氨酸脫羧酶1，別名GAD67。這是一種在大腦中表達(dá)的酶，負(fù)責(zé)催化谷氨酸轉(zhuǎn)化為抑制性神經(jīng)遞質(zhì)γ-氨基丁酸（GABA）。GAD1在神經(jīng)系統(tǒng)和內(nèi)分泌系統(tǒng)中表達(dá)，涉及突觸傳遞和胰島素分泌。在腫瘤學(xué)中，GAD1在多種腫瘤中異常上調(diào)表達(dá)，其高表達(dá)與結(jié)直腸癌的臨床分期及生存時(shí)間密切相關(guān)，并可能在腫瘤細(xì)胞適應(yīng)低氧、低pH微環(huán)境中起重要作用。GAD1的異常表達(dá)可能通過影響CTCF與DNA的結(jié)合，改變基因的甲基化模式，從而激活基因表達(dá)。在腫瘤細(xì)胞中，GAD1可能通過調(diào)節(jié)氨基酸穩(wěn)態(tài)來支持細(xì)胞增殖，這一作用與其在GABA代謝中的角色不同。GAD1的這些功能在調(diào)節(jié)神經(jīng)系統(tǒng)功能和腫瘤生物學(xué)中具有重要的生物學(xué)意義。
熱銷產(chǎn)品
GAD1 Antibody (CSB-PA858702ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Glutamate decarboxylase 1 antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67, 26, 48 kDa
Observed band size: 67 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858702ESR1HU at dilution of 1:100
Human glutamic acid decarboxylase,GAD ELISA Kit (CSB-E09199h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E09199h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
GAD1 Antibodies
GAD1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA858702ESR1HU | GAD1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA858702ESR2HU | GAD1 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-PA087198 | GAD1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA142729 | GAD1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008568 | GAD1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA102201 | GAD1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA219867 | GAD1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA981570 | GAD1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
GAD1 Proteins
GAD1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP858702HU CSB-EP858702HU CSB-BP858702HU CSB-MP858702HU CSB-EP858702HU-B |
Recombinant Human Glutamate decarboxylase 1 (GAD1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GAD1 ELISA Kit
GAD1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09199h | Human glutamic acid decarboxylase,GAD ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
