FCRL5
FCRL5全稱為Fc受體樣蛋白5，也被稱為FcRH5或CD307，是一種主要表達(dá)于B細(xì)胞表面的跨膜蛋白。它與免疫球蛋白Fc段結(jié)構(gòu)類似，但功能不同于傳統(tǒng)Fc受體，在B細(xì)胞發(fā)育和活化中具有獨(dú)特調(diào)節(jié)作用。FCRL5通過胞內(nèi)ITAM結(jié)構(gòu)域參與調(diào)控B細(xì)胞受體信號(hào)，其異常表達(dá)可能打破免疫耐受，與類風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等自身免疫病密切相關(guān)。近年來在腫瘤領(lǐng)域中發(fā)現(xiàn)，F(xiàn)CRL5在多發(fā)性骨髓瘤、彌漫大B細(xì)胞淋巴瘤等B細(xì)胞惡性腫瘤中特異性高表達(dá)，已成為新型治療靶點(diǎn)。
針對(duì)FCRL5的藥物研發(fā)主要聚焦雙特異性抗體和CAR-T療法。2021年進(jìn)入臨床試驗(yàn)的Cevostamab是全球首個(gè)靶向FCRL5的雙抗藥物，通過同時(shí)結(jié)合CD3和FCRL5激活T細(xì)胞殺傷腫瘤，在復(fù)發(fā)/難治性多發(fā)性骨髓瘤中已顯示出客觀緩解。利用FCRL5作為CAR-T靶點(diǎn)的臨床前研究也取得突破，其特異性表達(dá)特點(diǎn)可減少對(duì)正常B細(xì)胞的影響。目前該靶點(diǎn)相關(guān)研究已獲得FDA孤兒藥資格認(rèn)定，未來可能為B細(xì)胞相關(guān)疾病提供更精準(zhǔn)的治療選擇。
熱銷產(chǎn)品
Recombinant Human Fc receptor-like protein 5 (FCRL5), partial (CSB-MP853494HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western blot analysis of extracts from Jurkat cells, using FCRL5 antibody.
FCRL5 Antibodies
FCRL5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA791000 | FCRL5 Antibody | Human | ELISA,WB |
| CSB-PA005263 | FCRL5 Antibody | Human | WB, ELISA |
| CSB-PA060251 | FCRL5 Antibody | Human | WB, ELISA |
| CSB-PA853494LA01HU | FCRL5 Antibody | Human | ELISA, IF |
| CSB-PA853494LB01HU | FCRL5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA853494LC01HU | FCRL5 Antibody, FITC conjugated | Human | |
| CSB-PA853494LD01HU | FCRL5 Antibody, Biotin conjugated | Human | ELISA |
FCRL5 Proteins
FCRL5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP718110MO CSB-EP718110MO CSB-BP718110MO CSB-MP718110MO CSB-EP718110MO-B |
Recombinant Mouse Fc receptor-like protein 5 (Fcrl5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCRL5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP853494HU CSB-EP853494HU CSB-BP853494HU CSB-EP853494HU-B |
Recombinant Human Fc receptor-like protein 5 (FCRL5), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP853494HU | Recombinant Human Fc receptor-like protein 5 (FCRL5), partial | Mammalian cell |
