FBXO6
F-box only protein 6 is a protein in humans that is encoded by FBXO6 gene. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
FBXO6 Antibodies
FBXO6 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA008515GA01HU | FBXO6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA873634ESR1HU | FBXO6 Antibody | Human | ELISA, WB, IHC |
| CSB-PA873634ESR2HU | FBXO6 Antibody | Human | ELISA, IHC |
FBXO6 Proteins
FBXO6 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP664851BO CSB-EP664851BO CSB-BP664851BO CSB-MP664851BO CSB-EP664851BO-B |
Recombinant Bovine F-box only protein 6 (FBXO6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP846061RA CSB-EP846061RA CSB-BP846061RA CSB-MP846061RA CSB-EP846061RA-B |
Recombinant Rat F-box only protein 6 (Fbxo6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP870789MO CSB-EP870789MO CSB-BP870789MO CSB-MP870789MO CSB-EP870789MO-B |
Recombinant Mouse F-box only protein 6 (Fbxo6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBXO6 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP873634HU CSB-EP873634HU CSB-BP873634HU CSB-MP873634HU CSB-EP873634HU-B |
Recombinant Human F-box only protein 6 (FBXO6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
