FBN1
FBN1 is a protein in humans that is encoded by FBN1 gene. [Fibrillin-1] Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function.
FBN1 Antibodies
FBN1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA142599 | FBN1 Antibody | Human | ELISA,IHC |
| CSB-PA008211 | FBN1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA917144 | FBN1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA107393 | FBN1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA008456LA01HU | FBN1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008456LB01HU | FBN1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008456LC01HU | FBN1 Antibody, FITC conjugated | Human |
FBN1 Proteins
FBN1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008456BO CSB-BP008456BO CSB-MP008456BO CSB-EP008456BO-B |
Recombinant Bovine Fibrillin-1 (FBN1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBN1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008456HU CSB-EP008456HU CSB-BP008456HU CSB-MP008456HU CSB-EP008456HU-B |
Recombinant Human Fibrillin-1 (FBN1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008456HU1 | Recombinant Human Fibrillin-1 (FBN1), partial | E.coli |
FBN1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP736825MO CSB-EP736825MO CSB-BP736825MO CSB-MP736825MO CSB-EP736825MO-B |
Recombinant Mouse Fibrillin-1 (Fbn1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBN1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886953PI CSB-EP886953PI CSB-BP886953PI CSB-MP886953PI CSB-EP886953PI-B |
Recombinant Pig Fibrillin-1 (FBN1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FBN1 ELISA Kit
FBN1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13141h | Human Fibrillin-1 (FBN1)ELISA Kit | serum, plasma, tissue homogenates. | 0.058 ng/ml. |
