F2
F2，即凝血酶原（Prothrombin），是一種在肝臟中合成的維生素K依賴性血漿糖蛋白。它由肝臟產(chǎn)生，是凝血級聯(lián)反應(yīng)中的關(guān)鍵成分，最終轉(zhuǎn)化為具有活性的凝血酶。F2的作用機(jī)制涉及其在凝血過程中的激活，當(dāng)F2被因子Xa和因子Va的復(fù)合物激活時，它會被轉(zhuǎn)化為凝血酶（F2a），凝血酶是一種絲氨酸蛋白酶，能夠催化纖維蛋白原轉(zhuǎn)化為不溶性的纖維蛋白，形成血栓，實(shí)現(xiàn)止血。此外，凝血酶還參與激活血小板和血管收縮，進(jìn)一步促進(jìn)止血過程。F2是維持血液流動性和防止出血的重要因子。它不僅在生理性止血中發(fā)揮作用，還在病理性血栓形成中起關(guān)鍵作用，如深靜脈血栓和動脈粥樣硬化等。F2的異常活性或調(diào)節(jié)失衡與多種凝血障礙和血栓性疾病有關(guān)，因此，它是血液凝固研究和抗凝治療的重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Prothrombin (F2) (CSB-YP007923HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
F2 Recombinant Monoclonal Antibody (CSB-RA912740A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA912740A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
F2 Antibody (CSB-PA007923LA01HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescent analysis of Hela cells using CSB-PA007923LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: F2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71 kDa
Observed band size: 71 kDa
F2 Antibodies
F2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000063 | Cleaved-F2 (R327) Antibody | Human | WB, ELISA |
| CSB-PA004840 | F2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008158 | F2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA437416 | F2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA877573 | F2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA007923LA01HU | F2 Antibody | Human | ELISA, WB, IF |
| CSB-PA007923LC01HU | F2 Antibody, FITC conjugated | Human | |
| CSB-RA912740A0HU | F2 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
F2 Proteins
F2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007923RA CSB-EP007923RA CSB-BP007923RA CSB-MP007923RA CSB-EP007923RA-B |
Recombinant Rat thrombin (F2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007923MO CSB-EP007923MO CSB-BP007923MO CSB-MP007923MO CSB-EP007923MO-B |
Recombinant Mouse Prothrombin (F2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007923HU | Recombinant Human Prothrombin (F2) | Yeast |
| CSB-EP007923HU | Recombinant Human Prothrombin (F2) | E.coli |
| CSB-BP007923HU CSB-MP007923HU CSB-EP007923HU-B |
Recombinant Human Prothrombin (F2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007923HU1 | Recombinant Human Prothrombin (F2),partial | E.coli |
F2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007923BO CSB-EP007923BO CSB-BP007923BO CSB-MP007923BO CSB-EP007923BO-B |
Recombinant Bovine Prothrombin (F2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Vaccinia virus (strain L-IVP) (VACV)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP333485VAD CSB-EP333485VAD CSB-BP333485VAD CSB-MP333485VAD CSB-EP333485VAD-B |
Recombinant Vaccinia virus Protein F15 (F2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP615212PI CSB-EP615212PI CSB-BP615212PI CSB-MP615212PI CSB-EP615212PI-B |
Recombinant Pig Prothrombin (F2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP689264MDAK CSB-EP689264MDAK CSB-BP689264MDAK CSB-MP689264MDAK CSB-EP689264MDAK-B |
Recombinant Microplitis demolitor bracovirus I-Kappa-B like protein F1 (F2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP728899PYX CSB-EP728899PYX CSB-BP728899PYX CSB-MP728899PYX CSB-EP728899PYX-B |
Recombinant Pongo abelii Prothrombin (F2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
F2 ELISA Kit
F2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14235h | Human Thrombin ELISA Kit | serum, plasma | 1.95 ng/mL |
