EXOSC5
EXOSC5 is a protein in humans that is encoded by EXOSC5 gene. Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
EXOSC5 Antibodies
EXOSC5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007893GA01HU | EXOSC5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA878857LA01HU | EXOSC5 Antibody | Human | ELISA, WB, IHC |
| CSB-PA878857LD01HU | EXOSC5 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA878857LC01HU | EXOSC5 Antibody, FITC conjugated | Human | |
| CSB-PA878857LB01HU | EXOSC5 Antibody, HRP conjugated | Human | ELISA |
EXOSC5 Proteins
EXOSC5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP878857HU CSB-EP878857HU CSB-BP878857HU CSB-MP878857HU CSB-EP878857HU-B |
Recombinant Human Exosome complex component RRP46 (EXOSC5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP883916MO CSB-EP883916MO CSB-BP883916MO CSB-MP883916MO CSB-EP883916MO-B |
Recombinant Mouse Exosome complex component RRP46 (Exosc5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
