EXOSC3
EXOSC3 is a protein in humans that is encoded by EXOSC3 gene. Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5.
EXOSC3 Antibodies
EXOSC3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007891GA01HU | EXOSC3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA889083LA01HU | EXOSC3 Antibody | Human | ELISA, IHC |
| CSB-PA889083LB01HU | EXOSC3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA889083LD01HU | EXOSC3 Antibody, Biotin conjugated | Human | ELISA |
EXOSC3 Proteins
EXOSC3 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP663601BO CSB-EP663601BO CSB-BP663601BO CSB-MP663601BO CSB-EP663601BO-B |
Recombinant Bovine Exosome complex component RRP40 (EXOSC3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC3 Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP741969DKK CSB-EP741969DKK CSB-BP741969DKK CSB-MP741969DKK CSB-EP741969DKK-B |
Recombinant Dictyostelium discoideum Putative exosome complex component rrp40 (exosc3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP756031MO CSB-EP756031MO CSB-BP756031MO CSB-MP756031MO CSB-EP756031MO-B |
Recombinant Mouse Exosome complex component RRP40 (Exosc3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP889083HU CSB-EP889083HU CSB-BP889083HU CSB-MP889083HU CSB-EP889083HU-B |
Recombinant Human Exosome complex component RRP40 (EXOSC3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
