EXOSC2
EXOSC2 is a protein in humans that is encoded by EXOSC2 gene. Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
EXOSC2 Antibodies
EXOSC2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007890GA01HU | EXOSC2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
EXOSC2 Proteins
EXOSC2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP613428HU CSB-EP613428HU CSB-BP613428HU CSB-MP613428HU CSB-EP613428HU-B |
Recombinant Human Exosome complex component RRP4 (EXOSC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP645613BO CSB-EP645613BO CSB-BP645613BO CSB-MP645613BO CSB-EP645613BO-B |
Recombinant Bovine Exosome complex component RRP4 (EXOSC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EXOSC2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP837694MO CSB-EP837694MO CSB-BP837694MO CSB-MP837694MO CSB-EP837694MO-B |
Recombinant Mouse Exosome complex component RRP4 (Exosc2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
