ERCC3
General transcription and DNA repair factor IIH helicase subunit XPB is a protein in humans that is encoded by ERCC3 gene. ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
ERCC3 Antibodies
ERCC3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007771GA01HU | ERCC3 Antibody | Human,Mouse,Rat | ELISA,WB |
ERCC3 Proteins
ERCC3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007771HU CSB-BP007771HU CSB-MP007771HU CSB-EP007771HU-B |
Recombinant Human General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007771HU | Recombinant Human General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) | E.coli |
ERCC3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007771MO CSB-EP007771MO CSB-BP007771MO CSB-MP007771MO CSB-EP007771MO-B |
Recombinant Mouse TFIIH basal transcription factor complex helicase XPB subunit (Ercc3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP632271BO CSB-EP632271BO CSB-BP632271BO CSB-MP632271BO CSB-EP632271BO-B |
Recombinant Bovine TFIIH basal transcription factor complex helicase XPB subunit (ERCC3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP674573RA CSB-EP674573RA CSB-BP674573RA CSB-MP674573RA CSB-EP674573RA-B |
Recombinant Rat TFIIH basal transcription factor complex helicase XPB subunit (Ercc3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Pongo abelii (Sumatran orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP712924PYX CSB-EP712924PYX CSB-BP712924PYX CSB-MP712924PYX CSB-EP712924PYX-B |
Recombinant Pongo abelii TFIIH basal transcription factor complex helicase XPB subunit (ERCC3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP723386MOV CSB-EP723386MOV CSB-BP723386MOV CSB-MP723386MOV CSB-EP723386MOV-B |
Recombinant Macaca fascicularis TFIIH basal transcription factor complex helicase XPB subunit (ERCC3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP726522CH CSB-EP726522CH CSB-BP726522CH CSB-MP726522CH CSB-EP726522CH-B |
Recombinant Chicken TFIIH basal transcription factor complex helicase XPB subunit (ERCC3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERCC3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP767240DIL CSB-EP767240DIL CSB-BP767240DIL CSB-MP767240DIL CSB-EP767240DIL-B |
Recombinant Danio rerio TFIIH basal transcription factor complex helicase XPB subunit (ercc3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
