EPHB3
EPHB3，全稱(chēng)為Ephrin type-B receptor 3，在人類(lèi)中由EPHB3基因編碼。該蛋白屬于受體酪氨酸激酶家族，與ephrin-B家族成員結(jié)合，參與細(xì)胞間通訊、細(xì)胞遷移和組織發(fā)育的調(diào)控。EPHB3蛋白在神經(jīng)系統(tǒng)發(fā)育中起關(guān)鍵作用，特別是在神經(jīng)嵴細(xì)胞遷移和腦區(qū)形成過(guò)程中。此外，它在血管生成和腸道上皮細(xì)胞排列中也發(fā)揮重要作用。EPHB3蛋白的常見(jiàn)別名包括Hek2和Tyro6。研究發(fā)現(xiàn)，EPHB3蛋白的異常表達(dá)與多種疾病相關(guān)，如神經(jīng)發(fā)育障礙、癌癥（如結(jié)腸癌和乳腺癌）以及炎癥性腸病。在結(jié)腸癌中，EPHB3蛋白的異常表達(dá)可能促進(jìn)腫瘤侵襲和轉(zhuǎn)移。針對(duì)EPHB3蛋白的藥物研發(fā)已取得一定進(jìn)展，例如開(kāi)發(fā)EphB3特異性抗體用于治療相關(guān)疾病。
熱銷(xiāo)產(chǎn)品
EPHB3 Antibody (CSB-PA007731LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate, NIH/3T3 whole cell lysate
All lanes: EPHB3 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 111 kDa
Observed band size: 111 kDa
Immunofluorescent analysis of Hela cells using CSB-PA007731LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
EPHB3 Antibodies
EPHB3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA637350 | EPHB3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA229924 | EPHB3 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA999015 | EPHB3 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA007731LA01HU | EPHB3 Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-PA007731LC01HU | EPHB3 Antibody, FITC conjugated | Human |
EPHB3 Proteins
EPHB3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007731HU CSB-EP007731HU CSB-BP007731HU CSB-MP007731HU CSB-EP007731HU-B |
Recombinant Human Ephrin type-B receptor 3 (EPHB3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
