EPHA5
EPHA5蛋白全稱為促紅細(xì)胞生成素肝細(xì)胞受體A5，屬于Eph受體酪氨酸激酶家族成員，在胚胎發(fā)育階段主導(dǎo)神經(jīng)軸突導(dǎo)向與突觸形成。EPHA5通過與細(xì)胞膜表面的ephrin-A配體結(jié)合，觸發(fā)雙向信號傳導(dǎo)，調(diào)控神經(jīng)細(xì)胞遷移和腫瘤微環(huán)境重塑。EPHA5在阿爾茨海默病患者海馬區(qū)呈現(xiàn)異常低表達(dá)，其介導(dǎo)的突觸修剪功能失調(diào)可能與tau蛋白過度磷酸化存在關(guān)聯(lián)。在非小細(xì)胞肺癌和膠質(zhì)母細(xì)胞瘤中，EPHA5的高表達(dá)與EGFR信號通路形成交叉調(diào)控，促進(jìn)腫瘤細(xì)胞侵襲轉(zhuǎn)移。針對該靶點的藥物開發(fā)聚焦于雙特異性抗體技術(shù)，通過阻斷Ephrin-A5/EPHA5相互作用抑制腫瘤血管生成，已有兩款候選藥物進(jìn)入臨床前安全性評價階段。該受體在視網(wǎng)膜退行性病變中表現(xiàn)出神經(jīng)保護(hù)作用，相關(guān)基因療法正在探索其在黃斑變性治療中的應(yīng)用潛力。
熱銷產(chǎn)品
EPHA5 Antibody (CSB-PA007725LA01HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate
All lanes: EPHA5 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 115, 113, 108 kDa
Observed band size: 115 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007725LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA007725LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
EPHA5 Antibodies
EPHA5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002363 | EPHA5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007725LA01HU | EPHA5 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA007725LB01HU | EPHA5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007725LC01HU | EPHA5 Antibody, FITC conjugated | Human | |
| CSB-PA007725LD01HU | EPHA5 Antibody, Biotin conjugated | Human | ELISA |
EPHA5 Proteins
EPHA5 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007725CH CSB-EP007725CH CSB-BP007725CH CSB-MP007725CH CSB-EP007725CH-B |
Recombinant Chicken Ephrin type-A receptor 5 (EPHA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007725RA CSB-EP007725RA CSB-BP007725RA CSB-MP007725RA CSB-EP007725RA-B |
Recombinant Rat Ephrin type-A receptor 5 (Epha5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007725HU CSB-EP007725HU CSB-BP007725HU CSB-MP007725HU CSB-EP007725HU-B |
Recombinant Human Ephrin type-A receptor 5 (EPHA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP736731MO CSB-EP736731MO CSB-BP736731MO CSB-MP736731MO CSB-EP736731MO-B |
Recombinant Mouse Ephrin type-A receptor 5 (Epha5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
