ENPP1
ENPP1，即外核苷酸焦磷酸酶/磷酸二酯酶1，別名PC-1、CD203c等。它是一種細胞外糖蛋白，由人體細胞自身的基因編碼，主要在免疫系統、骨代謝和能量代謝中發揮作用。ENPP1的作用機制包括水解細胞外的核苷酸三磷酸產生焦磷酸鹽，這一過程在骨礦化和胰島素信號傳導中具有重要作用。此外，ENPP1還能通過水解免疫遞質2'3'-環GMP-AMP（cGAMP）來抑制STING信號通路，從而調節先天免疫反應 。ENPP1在生物學上的意義非常廣泛，它參與多種生理和病理過程，包括骨礦化、胰島素信號傳導、腫瘤免疫逃逸等。ENPP1的表達與多種疾病相關，例如在腫瘤微環境中，ENPP1的高表達與不良預后相關，其水解cGAMP活性可能抑制了cGAS-STING通路，從而抑制了抗腫瘤免疫反應 。此外，ENPP1還可能參與調節細胞外ATP/腺苷平衡，影響腫瘤微環境中的免疫細胞浸潤和功能 。因此，ENPP1是免疫生物學研究和癌癥治療中的一個潛在靶點。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ENPP1 Antibody (CSB-PA007679LA01HU)
驗證數據
Immunofluorescent analysis of HepG2 cells using CSB-PA007679LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
驗證數據
貨號：CSB-EL007679MO
規格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ENPP1 Proteins
ENPP1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP007679MO CSB-MP007679MO CSB-EP007679MO-B |
Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007679MO | Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | E.coli |
| CSB-YP007679MO | Recombinant Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Enpp1), partial | Yeast |
ENPP1 ELISA Kit
ENPP1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007679MO | Mouse Ectonucleotide pyrophosphatase/phosphodiesterase family member 1(ENPP1) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
