EIF4E
EIF4E，即真核翻譯起始因子4E，別名eIF4E，是mRNA翻譯的關鍵調控者，源自真核生物細胞。它通過綁定mRNA的5'端帽子結構，引領翻譯機器到達mRNA的起始點，解鎖mRNA，使之能與核糖體結合，啟動蛋白質合成。EIF4E不僅調控基因表達的速度與程度，還參與mRNA穩定性、轉運與降解等多個細胞過程。在生物學上，EIF4E的異常調控與多種疾病相關，特別是其高表達常被發現于腫瘤中，成為腫瘤增殖與抗藥性的關鍵因素。因此，EIF4E成為抗癌療法的新靶點，具有重要的研究與應用價值。
熱銷產品
Phospho-EIF4E (S209) Recombinant Monoclonal Antibody (CSB-RA007556A209phHU)
驗證數據
Western Blot
Positive WB detected in 293 whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or not)
All lanes Phospho-EIF4E antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 KDa
Observed band size: 25 KDa
IHC image of CSB-RA007556A209phHU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
EIF4E Antibodies
EIF4E for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007556GA01HU | EIF4E Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA935753 | Phospho-EIF4E (Ser209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA190338 | EIF4E (Ab-209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000519 | Phospho-EIF4E (S209) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002308 | EIF4E Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA007556LA01HU | EIF4E Antibody | Human | ELISA, IHC, IF |
| CSB-PA007556LB01HU | EIF4E Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007556LC01HU | EIF4E Antibody, FITC conjugated | Human | |
| CSB-PA007556LD01HU | EIF4E Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA007556A209phHU | Phospho-EIF4E (S209) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
EIF4E Proteins
EIF4E Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556RB CSB-EP007556RB CSB-BP007556RB CSB-MP007556RB CSB-EP007556RB-B |
Recombinant Rabbit Eukaryotic translation initiation factor 4E (EIF4E) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556MO CSB-EP007556MO CSB-BP007556MO CSB-MP007556MO CSB-EP007556MO-B |
Recombinant Mouse Eukaryotic translation initiation factor 4E (Eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP007556HU CSB-BP007556HU CSB-MP007556HU CSB-EP007556HU-B |
Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP007556HU | Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E) | Yeast |
EIF4E Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556XBE CSB-EP007556XBE CSB-BP007556XBE CSB-MP007556XBE CSB-EP007556XBE-B |
Recombinant Xenopus laevis Eukaryotic translation initiation factor 4E (eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556RA CSB-EP007556RA CSB-BP007556RA CSB-MP007556RA CSB-EP007556RA-B |
Recombinant Rat Eukaryotic translation initiation factor 4E (Eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Dictyostelium discoideum (Slime mold)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556DKK CSB-EP007556DKK CSB-BP007556DKK CSB-MP007556DKK CSB-EP007556DKK-B |
Recombinant Dictyostelium discoideum Eukaryotic translation initiation factor 4E (eif4e) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF4E Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007556BO CSB-EP007556BO CSB-BP007556BO CSB-MP007556BO CSB-EP007556BO-B |
Recombinant Bovine Eukaryotic translation initiation factor 4E (EIF4E) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
