DRD5
DRD5，即多巴胺受體D5，別名DRD1B、DRD1L2。這是一種G蛋白偶聯(lián)受體（GPCR），主要在大腦邊緣區(qū)域的神經(jīng)元中表達(dá)，尤其在前額葉皮層和海馬體中。DRD5的作用機(jī)制涉及與多巴胺的結(jié)合，激活G蛋白，進(jìn)而影響細(xì)胞內(nèi)信號(hào)傳導(dǎo)，包括cAMP水平的變化和離子通道的調(diào)節(jié)。DRD5在調(diào)節(jié)認(rèn)知功能、情緒和運(yùn)動(dòng)控制中起著重要作用。它與多巴胺系統(tǒng)的其他受體一起，參與調(diào)節(jié)獎(jiǎng)賞、動(dòng)機(jī)和注意力等過(guò)程。DRD5的異常表達(dá)或功能與多種神經(jīng)精神疾病相關(guān)，包括精神分裂癥、帕金森病和藥物成癮。此外，DRD5也是藥物開(kāi)發(fā)的重要靶點(diǎn)，其激動(dòng)劑可能有助于治療認(rèn)知障礙和神經(jīng)退行性疾病。研究還發(fā)現(xiàn)，多巴胺通過(guò)DRD5-ARRB2-PP2A信號(hào)軸抑制TRAF6介導(dǎo)的NF-κB炎癥信號(hào)和系統(tǒng)性炎癥反應(yīng)，揭示了DRD5在神經(jīng)免疫調(diào)節(jié)中的新機(jī)制。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA568903(DRD5 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human ovarian cancer tissue, Primary antibody: CSB-PA568903(DRD5 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
DRD5 Antibodies
DRD5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA007182GA01HU | DRD5 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA007182EA01HU | DRD5 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA007182EC01HU | DRD5 Antibody, FITC conjugated | Human | |
| CSB-PA568903 | DRD5 Antibody | Human | ELISA,WB,IHC |
DRD5 Proteins
DRD5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007182HU1 CSB-EP007182HU1 CSB-BP007182HU1 CSB-MP007182HU1 CSB-EP007182HU1-B |
Recombinant Human D (1B) dopamine receptor (DRD5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007182HU | Recombinant Human D (1B) dopamine receptor (DRD5) | in vitro E.coli expression system |
DRD5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP007182RA1 CSB-EP007182RA1 CSB-BP007182RA1 CSB-MP007182RA1 CSB-EP007182RA1-B |
Recombinant Rat D (1B) dopamine receptor (Drd5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007182RA | Recombinant Rat D (1B) dopamine receptor (Drd5) | in vitro E.coli expression system |
DRD5 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP331478XBE1 CSB-EP331478XBE1 CSB-BP331478XBE1 CSB-MP331478XBE1 CSB-EP331478XBE1-B |
Recombinant Xenopus laevis D (1B) dopamine receptor, partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF331478XBE | Recombinant Xenopus laevis D (1B) dopamine receptor | in vitro E.coli expression system |
DRD5 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP804368MO1 CSB-EP804368MO1 CSB-BP804368MO1 CSB-MP804368MO1 CSB-EP804368MO1-B |
Recombinant Mouse D (1B) dopamine receptor (Drd5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF804368MO | Recombinant Mouse D (1B) dopamine receptor (Drd5) | in vitro E.coli expression system |
DRD5 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP850127BO CSB-EP850127BO CSB-BP850127BO CSB-MP850127BO CSB-EP850127BO-B |
Recombinant Bovine D (1B) dopamine receptor (DRD5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DRD5 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP853260MOW CSB-EP853260MOW CSB-BP853260MOW CSB-MP853260MOW CSB-EP853260MOW-B |
Recombinant Macaca mulatta D (1B) dopamine receptor (DRD5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
