DNMT1
DNMT1，即DNA甲基轉移酶1，別名AIM、DNMT、MCMT、CXXC9、HSN1E、ADCADN、m.HsaI等。DNMT1由人類DNMT1基因編碼，該基因位于19號染色體上。DNMT1是一種酶，負責在DNA復制過程中將甲基基團轉移至新合成的DNA鏈上，以維持DNA甲基化模式的穩定性和遺傳信息的傳遞。其作用機制主要是通過識別半甲基化的DNA并催化甲基化反應，對維持基因表達模式和基因沉默至關重要。DNMT1在調控基因表達、胚胎發育、細胞分化以及腫瘤發生中扮演重要角色。異常的DNA甲基化模式與多種疾病相關，包括癌癥和發育異常。
熱銷產品
DNMT1 Recombinant Monoclonal Antibody (CSB-RA160202A0HU)
驗證數據
IHC image of CSB-RA160202A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of HepG2 Cells with CSB-RA160202A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
DNMT1 Antibodies
DNMT1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA106123 | DNMT1 Antibody | Human | ELISA,IHC |
| CSB-PA183398 | DNMT1 Antibody | Human | ELISA,IHC |
| CSB-PA007082HA01HU | DNMT1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA007082HB01HU | DNMT1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007082HC01HU | DNMT1 Antibody, FITC conjugated | Human | |
| CSB-PA007082HD01HU | DNMT1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA160202A0HU | DNMT1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
DNMT1 Proteins
DNMT1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007082MO CSB-EP007082MO CSB-BP007082MO CSB-MP007082MO CSB-EP007082MO-B |
Recombinant Mouse DNA (cytosine-5)-methyltransferase 1 (Dnmt1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007082HU CSB-EP007082HU CSB-BP007082HU CSB-MP007082HU CSB-EP007082HU-B |
Recombinant Human DNA (cytosine-5)-methyltransferase 1 (DNMT1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP630525BO CSB-EP630525BO CSB-BP630525BO CSB-MP630525BO CSB-EP630525BO-B |
Recombinant Bovine DNA (cytosine-5)-methyltransferase 1 (DNMT1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP838724CH CSB-EP838724CH CSB-BP838724CH CSB-MP838724CH CSB-EP838724CH-B |
Recombinant Chicken DNA (cytosine-5)-methyltransferase 1 (DNMT1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
