DKK2
DKK2，全稱為Dickkopf-related protein 2，是一種分泌性蛋白，在多種組織中表達(dá)。該蛋白屬于Dickkopf家族，與Wnt信號(hào)通路密切相關(guān)。DKK2蛋白通過(guò)抑制Wnt信號(hào)通路的傳導(dǎo)，參與多種生理和病理過(guò)程，如細(xì)胞增殖、分化、凋亡和組織發(fā)育等。研究表明，DKK2蛋白的表達(dá)增強(qiáng)與多種癌癥的發(fā)生發(fā)展密切相關(guān)，如結(jié)直腸癌、膀胱癌、肝癌等。此外，DKK2蛋白也與一些骨骼疾病相關(guān)。基于DKK2蛋白的作用機(jī)制，研究人員正在開(kāi)發(fā)針對(duì)DKK2蛋白的藥物，用于癌癥和骨骼疾病的防治。
熱銷產(chǎn)品
Recombinant Human Dickkopf-related protein 2 (DKK2) (CSB-EP866207HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DKK2 Antibody (CSB-PA08279A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: DKK2 antibody at 3.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 29 kDa
Observed band size: 32 kDa
IHC image of CSB-PA08279A0Rb diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA08279A0Rb diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Dickkopf-related protein 2(DKK2) ELISA kit (CSB-EL006921HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL006921HU
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
DKK2 Antibodies
DKK2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA08279A0Rb | DKK2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA08279D0Rb | DKK2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA694579 | DKK2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA284301 | DKK2 Antibody | Human,Mouse | ELISA,WB |
DKK2 Proteins
DKK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP865601MO CSB-BP865601MO CSB-MP865601MO CSB-EP865601MO-B |
Recombinant Mouse Dickkopf-related protein 2 (Dkk2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DKK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP866207HU CSB-BP866207HU CSB-MP866207HU CSB-EP866207HU-B |
Recombinant Human Dickkopf-related protein 2 (DKK2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP866207HU | Recombinant Human Dickkopf-related protein 2 (DKK2) | E.coli |
DKK2 ELISA Kit
DKK2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006921HU | Human Dickkopf-related protein 2(DKK2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
